I took imipramine for years and years, only half worked but half is better than none. It quit working.
I'm tired of taking all that stuff but I would have acute episodes in my 30's due to an unhappy marriage. I've always thought that if it weren't for these meds, I would have spent most of my life in a mental hospital. And it would have been shorter.
I've been though h*** this past year. My son killed himself on Dec 5, 2012. Some days my mood is stable as long as I keep busy. The minute my mind starts to wander, it's like everything I worked for and struggled for was for nothing and I miss my son so bad.
He left $1.5 mil life insurance, and changed the beneficiaries to my daughters. His wife is contesting it. I can't stand to look at her knowing it was because of her but I ache for the little 3-year-old son he left behind.
I have to go on and don't know if I'll ever see him again. His last words were he was done with me because I called the police trying to get him locked up long enough so he wouldn't kill himself.
I kind of blame myself for passing the family gene onto him only they said he was a little bi polar. Well, I am, too, but nobody accused me of that yet. I have depression, anxiety, disthymia, and OCD.
Side effects seem to be much less common with SAMe than with SSRIs or the others. Of course, someone, somewhere, has a reaction to anything.
It is available many places, for example Costco and Rite-Aid.
Many doctors in North America have never heard of it. It is not actually a drug: it is a naturally occurring substance in the brain.
S-adenosyl-l-methionine (SAMe) as antidepressant: meta-analysis of clinical studies. Bressa GM.
Department of Psychiatry, University Cattolica Sacro Cuore School of Medicine, Rome, Italy. Abstract
S-adenosyl-l-methionine (SAMe) is a naturally-occurring substance which is a major source of methyl groups in the brain.
MATERIAL AND METHODS: We conducted a meta-analysis of the studies on SAMe to assess the efficacy of this compound in the treatment of depression compared with placebo and standard tricyclic antidepressants.
RESULTS: Our meta-analysis showed a greater response rate with SAMe when compared with placebo, with a global effect size ranging from 17% to 38% depending on the definition of response, and an antidepressant effect comparable with that of standard tricyclic antidepressants.
CONCLUSION: The efficacy of SAMe in treating depressive syndromes and disorders is superior with that of placebo and comparable to that of standard tricyclic antidepressants. Since SAMe is a naturally occurring compound with relatively few side-effects, it is a potentially important treatment for depression.
PMID: 7941964 [PubMed - indexed for MEDLINE]