I suppose that I am lucky.
The first time I ever tried tylenol it gave me a terrible headache. It did the same for my siblings. I’ve never taken it since.
Tylenol has not more effect on me than an m&m would. But since I have a chronic pain problem, I take an ibuprophen once a day and sometimes twice. That’s probably not good either but you have to trade off sometimes. A case of choose your poison I suppose.