In a word, no. I have a female friend who has had premarital sex and it doesn’t affect our friendship one bit. Mostly we don’t talk about it. What would be the point? I know I’m not going to change the way she lives and she’s not going to change the way I live. It’s not like anything I say can ever make her a virgin again. So yes, it is possible to oppose the lifestyle choice of premarital sex without alienating friends and family or resorting to petty name-calling.