Free Republic
Browse · Search
News/Activism
Topics · Post Article

Skip to comments.

Stress signal causes abnormal implantation location and pregnancy loss
Journal of Biological Chemistry ^ | 2011-2-25 | Journal of Biological Chemistry

Posted on 08/21/2012 11:10:29 AM PDT by Maelstorm

Pregnancy loss is a common and painful condition for gestational women, accounting for 25-40% of total pregnancy, having become a serious social-medical issue worldwide. Animal studies and clinical investigations have indicated that the cause of many mid-term miscarriage/abnormal pregnancy has been seeded very early during the onset of embryo implantation. Epidemiological study also showed that maternal stress at early pregnancy is strongly associated with various complications during ongoing gestation. However, whether and how the process of embryo implantation is affected by environmental factors such as stress induced sympathetic activation remained elusive. Considering the mammalian uterus is an organ with extensive sympathetic innervations, the research group leads by Prof. Enkui Duan at Institute of Zoology, Chinese Academy of Sciences hypothesized that it is possible that around the time of embryo implantation, stress-induced sympathetic activation may directly affect embryo-maternal interactions through adrenergic receptors, therefore affecting the quality of ongoing pregnancy.

By using mouse model, the research group found an unexpected, transient effect of β2-Adrenoceptor (β2-AR) activation (Day4 postcoitus) in disrupting embryo spacing at implantation (without changing implantation timing), leading to substantially increased mid-term pregnancy loss. In vitro and in vivo studies demonstrated that the transient β2-AR activation abolished normal preimplantation uterine contractility, without adversely affecting blastocyst quality. The contractility inhibition is mediated by activation of cAMP-PKA pathway and accompanied with specific downregulation of lpa3, a gene previously found to be critical for uterine contraction and embryo spacing. These results recapitulated the concept that “on-site” intrauterine embryo location mediated by concerted uterine contraction is crucial for successful ongoing pregnancy.

(Excerpt) Read more at rpb.ioz.ac.cn ...


TOPICS: Culture/Society; News/Current Events; US: Missouri
KEYWORDS: akin; miscarriage; pregnancy; stress
Navigation: use the links below to view more comments.
first 1-2021-4041-6061-63 next last
Finally found what I was looking for. Strange how in a rush to condemn one often gives up the potential to learn something.
1 posted on 08/21/2012 11:10:36 AM PDT by Maelstorm
[ Post Reply | Private Reply | View Replies]

To: Maelstorm

Well, well, well..........


2 posted on 08/21/2012 11:16:58 AM PDT by Red Badger (Anyone who thinks wisdom comes with age is either too young or too stupid to know the difference....)
[ Post Reply | Private Reply | To 1 | View Replies]

To: Maelstorm

The ole rush to judgement again!


3 posted on 08/21/2012 11:19:26 AM PDT by b4its2late (A Liberal is a person who will give away everything he doesn't own.)
[ Post Reply | Private Reply | To 1 | View Replies]

To: Maelstorm

Nope, sorry, this can’t be right. Four out of five experts at FreeRepublic agree this is bull$hit. There is no magic button that turns off the pregnancy machinery during rape.

Besides, this was probably written by a man, who knows nothing about women’s bodies.


4 posted on 08/21/2012 11:20:27 AM PDT by LearsFool ("Thou shouldst not have been old, till thou hadst been wise.")
[ Post Reply | Private Reply | To 1 | View Replies]

To: Maelstorm

I would bet that millions of government dollars have been spent on studies having something to do with preventing stress from destroying a pregnancy - probably funding supported by Democraats. For what it’s worth.


5 posted on 08/21/2012 11:26:24 AM PDT by cvq3842 (Thanks for all responses, and flames, in advance.)
[ Post Reply | Private Reply | To 1 | View Replies]

To: Maelstorm

We’re in a society where science and facts don’t matter; all that matters is what the media can get people to believe.

I think that’s the definition of post-modernism, and it is one of the last steps before the death of a society.

Sad.


6 posted on 08/21/2012 11:27:55 AM PDT by butterdezillion
[ Post Reply | Private Reply | To 1 | View Replies]

To: Maelstorm

This is a horrific insult to any women who has ever been impregnated by a rapist. Basically, you’re saying, just as that nitwit Akin said: if a women reports that she was raped and is then impregnated, it wasn’t rape after all? She enjoyed it? SHe asked for it?

Please explain.


7 posted on 08/21/2012 11:28:26 AM PDT by EnquiringMind
[ Post Reply | Private Reply | To 1 | View Replies]

To: Maelstorm
Thank you!

I've been on the net for the last three hours trying to find something to bolster my comment of yesterday that wondered whether a raped woman secreted adrenaline or some other antigen that would make her womb inhospitable to unwanted sperm.

Freepers tore into me for my stupidity!

8 posted on 08/21/2012 11:32:40 AM PDT by Noob1999 (Loose Lips, Sink Ships)
[ Post Reply | Private Reply | To 1 | View Replies]

To: Noob1999

This should be very simple to determine. I’m sure there are statistics on pregnancy rates of rape victims. This can be compared to the risk of pregnancy for a one-time sexual encounter.


9 posted on 08/21/2012 11:45:10 AM PDT by Hillary'sMoralVoid
[ Post Reply | Private Reply | To 8 | View Replies]

To: EnquiringMind

Are you being serious or just doing a darn good immitation of an FR bed wetter?


10 posted on 08/21/2012 11:45:11 AM PDT by MEGoody (You shall know the truth, and the truth shall make you free.)
[ Post Reply | Private Reply | To 7 | View Replies]

To: EnquiringMind

This is a horrific insult to any women who has ever been impregnated by a rapist. That would be a false perception.

Usually it is dems that are insulted by truth. We do know that rape and incest pregnancies, are extremely rare.


11 posted on 08/21/2012 11:47:32 AM PDT by wita
[ Post Reply | Private Reply | To 7 | View Replies]

To: Noob1999

“Freepers tore into me for my stupidity!”

That should be a major insult to “real” freepers.


12 posted on 08/21/2012 11:51:31 AM PDT by wita
[ Post Reply | Private Reply | To 8 | View Replies]

To: Noob1999

Then you must be really P.Oed at Akin. First he spoke your truth then he apologized and called it a lie.


13 posted on 08/21/2012 12:04:04 PM PDT by DManA
[ Post Reply | Private Reply | To 8 | View Replies]

To: Maelstorm

If they are saying that women so traumatized and shaken are at a higher risk of miscarriage, then yes, that’s likely true.

That’s a long way from what Akin said.


14 posted on 08/21/2012 12:13:42 PM PDT by Buckeye McFrog
[ Post Reply | Private Reply | To 1 | View Replies]

To: Maelstorm

Nice find. There is a difference between reduce the chance and eliminate all possibility, and so there is a difference between rare and non-existant. The first problem is that most people aren’t up for subtle distinctions, and the second is that poorly phrased it is a loosing issue. That said, if one is interested in truth and life, the facts are worth thinking about.


15 posted on 08/21/2012 12:15:48 PM PDT by Hieronymus ( (It is terrible to contemplate how few politicians are hanged. --G.K. Chesterton))
[ Post Reply | Private Reply | To 1 | View Replies]

To: EnquiringMind

This issue involves statistics and probability. I think you didn't understand the point of the article.

16 posted on 08/21/2012 12:32:17 PM PDT by fishtank (The denial of original sin is the root of liberalism.)
[ Post Reply | Private Reply | To 7 | View Replies]

To: Maelstorm

A ChiCom study. Really?


17 posted on 08/21/2012 12:35:28 PM PDT by jboot (This isn't your father's America. Stay safe and keep your powder dry.)
[ Post Reply | Private Reply | To 1 | View Replies]

To: jboot

Bookmark


18 posted on 08/21/2012 12:38:36 PM PDT by publius911 (Formerly Publius 6961, formerly jennsdad)
[ Post Reply | Private Reply | To 17 | View Replies]

To: Maelstorm

Thanks, Maelstrom. I’m still of the opinion that factors such as this are not enough to make pregnancy resulting from rape “rare,” but it’s useful to see the research and the possible mechanisms at work.

I’m not going to criticize this for being an experiment on mice, because one of the articles I posted, that acute stress may induce ovulation, largely relied on animal models as well.

Human reproduction differs from the reproduction of other mammals and I don’t think animal experiments can settle the quesstion.


19 posted on 08/21/2012 12:53:02 PM PDT by heartwood
[ Post Reply | Private Reply | To 1 | View Replies]

To: EnquiringMind
It would seem that I’m jumping into the middle of an argument here so forgive me if I’m not aware of what may have been discussed previously. I think one of the issues at hand with this article is the phrase “substantially increased mid-term pregnancy loss”. Statistically this could be just a few percentage points and it also refers to mid-term. Unfortunately rape victims may still implant and show pregnancy within the first few weeks. I’m sure most such pregnancies are aborted before midterm and this may skew human data on the survivability of the embryo.

In plain English this journal appears to be saying that stress reduces the chance of a full term pregnancy. Personal antidotal evidence suggests this may be true since my girl friend lost 4 pregnancies with her ex-husband and she was very stressed during that marriage.

As far at this notion that if you were raped you shouldn’t get pregnant - I don’t know where that started but the idea is reprehensible (IMO).
20 posted on 08/21/2012 12:53:47 PM PDT by chaos_5
[ Post Reply | Private Reply | To 7 | View Replies]


Navigation: use the links below to view more comments.
first 1-2021-4041-6061-63 next last

Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.

Free Republic
Browse · Search
News/Activism
Topics · Post Article

FreeRepublic, LLC, PO BOX 9771, FRESNO, CA 93794
FreeRepublic.com is powered by software copyright 2000-2008 John Robinson