No idea, but if it doesn’t get through the stomach/intestinal lining I’d think skin penetration may be even more difficult. Dunno though.
I admit I haven’t read the literature so fair caveat, BUT after studing Neuroscience for decades before, during, and after Medical School I would have to say any attempt to equate in vitro binding or inhibition of a complex protein with neurofibrillary tangles with clinical significance is so dumb it could only come from a libtard. It is like sending a 4 year old with a Viking’s ticket to a Mets game.
Suppositories - better than many other dose formats. My prior company had a lot of Rx products in suppositories. Europeans still utilize them heavily but in the U.S. there is still an aversion after all these years. But they work and the patient avoids all the nasty digestive problems. If drugs like Interferon could be adapted - wow.