Four full cups of wine (Passover Seder) will do a lot of people in.
ML/NJ
Me too. Pacing and portion size are the secret.
From the site I linked to before: Drinking on Purim
The rabbis of the Talmud paid close attention to the nature of the obligation. On Passover, the four cups of wine are for joy and for sanctification, but they also have symbolic associations with the expressions that God used for Israel's redemption. On Purim, however, the wine (or liquor) is not symbolic. It is functional. Consequently, the nature of the obligation is not defined by volume, but rather, by the effect upon the drinker.