Get hits.
Get lots of hits.
I just had the occasion to shoot what the guys called my "Europellet gun" (Glock 17) with two guys shooting .45ACP compact pistols in a tactical exercise under stress.
I got lots of hits. Lots more hits than the .45ACP guys.
In a gunfight, hits are the thing. If two hits don't work, get more.
Hell, the first hit is usually what counts which is why being comfortable and well practiced with your weapon is more important than the caliber used. If someone breaks into your home, even if the first hit doesn’t stop the perp, unless he is tweaked out on meth or something like that, it will make him think twice about getting hit a second time.