The three most important words are accuracy, accuracy and accuracy.
Forget all the talk about +P loads and 125 grain versus 110 grain and all of that crap that the smoke-sniffers love so much. (Love ya, guys!) It’s fun to discuss but none if it matters when the volume gets turned up to LOUD.
Should the time come (heaven forbid) when you must draw and fire then the key becomes how precisely you can place that slug. One round, of any caliber or weight, placed accurately, WILL decide the argument.
Go to the range regularly and become intimate with your new friend. Shoot and shoot and shoot some more. Then go back in a week and do it again.
Accuracy. Never leave home without it.
I didn’t realize how hard ammo was to get with the .380. I finally was able to buy another 400 rounds about a month ago, so now need to start practicing more with it after being laid up injured for about 4 months.