In theory only. Somehow, we the people need to restore this theory to practice.
Get some judges who will inform juries that for a conviction they must find that the particular act of the defendant materially interfered with a legitimate exercise of a specific enumerated federal power. Congress may have the authority, via the elastic clause, to restrict actions which interfere with its ability to regulate interstate commerce, but only a jury armed with the particular facts of a case can know whether the particular action did in fact interfere with Congress' authority.