[texgal]

In my job at a major medical center, I monitor drug and device trials in humans and animals. Some researchers are very good and are aware of the reporting regulations while others are not. More work needs to be done at the local/institutional level to ensure that proper reporting of adverse events, severe adverse events and other requirements.

We've seen entire studies where not one single adverse event has been reported during the study and gone in and audited only to find many unreported AE's. This is why you end up with drugs like Avandia killing people.

[WaterBoard]

It’s because of greed. Drugs like Vioxx were generating billions of dollars in annual sales and were dangerous. But, the doctors that reviewed it got paid, the sales reps that sold it got paid, the ad firms that marketed it got paid, and the pharmacies that gave it to patients got their markup.

There is no incentive along the way to question a new drug.

Another one is Lipitor. There are many reports in patients of rhabodmyolysis yet most doctors never bother to liver enzyme checks in patients reporting leg pain.

I think in the future you will see most statins removed from the market. Yes, some will reduce you total cholesterol level. But there is no correlation in lower cholesterol and reduced morbidity or mortality according to AZ own studies. JMHO.

[brewer1516]

http://clinicaltrials.gov/