[neverdem]

Single-cell protein induction dynamics reveals a period of vulnerability to antibiotics in persister bacteria

[neverdem]

micro ping

[skr]

Very interesting

[Myrddin]

Antibiotics in the penicillin class mimic the building blocks of the peptidoglycan mesh that supports the cell membrane. The penicillin molecule can attach onto the polymerizing strand of peptidoglycan, but offers no subsequent attachment point. Do that enough and the mesh "bag" ruptures. This approach only works if the bacterium is actively growing, dividing and creating new cell wall material. The tetracycline class of antibiotics is bacteriostatic. Tetracycline mimics PABA (para-amino-benzoic acid) without providing the biological functionality of PABA. The bacterium ceases growing and begins to degrade and die because it can't maintain the cell walls and internal structures.

The "finding" makes perfectly good sense. Supplementing the nutrients to induce growth puts the bacterium in a state where the bio-active nature of a given antibiotic can operate as designed.

[Ka-leo-lani]

This is exciting news. This provides understanding why some infections do not heal. I wonder if my doctor already knows about this.

[Smokin' Joe]

Ping....(better late than never, Thanks, neverdem!)

[BellStar]

Another UTI! I am taking this to my Doctor this morning.
Thanks neverdem.