Alcohol and tobacco use are severly restricted.
Restricted by age (18/21).
Restricted by vendor (authorized importer/distrubtor/distiller/vendor only, no unliscensed resale).
Restricted by hours of sale (alcohol is only available 24 hours in 3 North American cities that I know of and one of those is in Canada).
You cannot have a 0.08 Blood Alcohol Content level and drive a car (even if impairment occurs at higher levels).
TABC (Texas Alcohol Beverage Commission) did a series of sweeps of bars (including hotel bars serving patrons of the hotel) arresting thousands of people for "public intoxication" in a six month period if they had ordered more than a couple of beers. And there is no requirement for a breatalizer test for a charge of "public intoxication".
The ATF (Alcohol - Tobacco - Firearms) do things differently than the DEA.
ZI'm sure there are more restrictions that can be cited.
And DRY counties still exist.
And, despite all those restrictions (you left out the high "sin" taxes imposed by all levels of government) teens still use tobacco and alcohol 2:1 over easy to get marijuana.