Walther PPK/S in .380 is a nice little weapon for a lady. There's also small j-frame revolvers from Smith&Wesson. If I had my druthers, I'd buy my lady one of the new Springfield XD line sub-compacts in 9mm.
I had a Walther PPK 380 and got rid of it.I am like the woman descibed, 5 feet tall and small hands. The spring on the Walther was too heavy and in order to slide it back my hand went over the barreel opening. That was unsafe so got a Sig 230. The only problem is that the feed on the 3 round shot hangs up and have to recock the gun. But the weight and ease of the slide is very nice and it points very nicely. Accuracy for the small barrell suck compared to my Smith 41 22lr target gun. But the Sig is not designed for target use.