[blackdog]

Vitamins E and A are fat soluble and not water soluble. (most forms that is)

All B vitamins and there's a bunch, are not those which accumulate in your system. They are passed right thru by your lungs, kidneys, and sweat. The fat solubles can build up in your system to toxic proportions. For example, one bite of a polar bear's liver contains enough vitamin A to kill a human. Most toxic minerals and vitamins accumulate in your liver. It's why chelation therapies work well in some people. Pass thru minerals like molybdenum will bind with copper or selenium etc....and take them out of your system because molybdenum gets a free pass right thru. If it's grabbed a few copper molecules on it's way, it detoxifies you.

[areafiftyone]

For example, one bite of a polar bear's liver contains enough vitamin A to kill a human.

Jeeze remind me to skip the "Polar Bear" section of my meat department in my supermarket tomorrow! ;-)

[Investment Biker]

I take a daily dose of multivitamin, a separate dose of B complex (includes 55mgs of B6, about 30x the RDA), and 300mg of Benfotiamine (a naturally occurring fat soluble allithiamine B1). The Benfotiamine dose is about 128 times the recommended dose of B1. There are no know side effects even at larger dosing of Benfotiamine.