Lexus has a hybrid out, but I agree, an E-class hybrid would make my head turn.
http://www.lexus.com/models/rx_preview.html?s_ocid=20099
The photo in #51 is a C320. (The E-class is a bit over my budget right now; I just bought a house)
The Mercedes link says that the fuel consumption on that model is 30 mpg.
Frankly, they'd have to do better than that for me to consider getting one. I average close to 30 mpg with my current C-class.