It's not the first though..
I recall playing a game called Fallout years ago where various drugs were used as powerups. They had negative effects though, the more you used them and you could even become addicted..
Still the setting was not "real world", it was set in a post nuclear war type setting.. radiation mutants and what-not.
Redneck Rampage, if you drank too much whiskey you couldn't walk straight.
Heck it goes further back than that. All the way to coin operated Mario Bros, they had shrink pills and grow pills and make everything look wierd pills, right out of White Rabbit.
yup that was a good one. This isn't anything new. Just another case of parents actually have to do some parenting and know what their kids are getting themselves into.