[neverdem]

Thanks for the link. I'm not satisfied with any of the explanations about prions. Your link was the first that I saw about "normal" prions. If prions are just misfolded proteins, what's their amino acid sequence and why do they induce misfolding in other proteins? Are the original proteins structural in nature or enzymes?

They need to do a lot more basic science in neurodegenerative disorders. Mice with knocked out genes have become the main model it seems. The author in this article seems to be the guy in the following abstract:

Prions: pathogenesis and reverse genetics.

[Carry_Okie]

Thanks for the link. I'm not satisfied with any of the explanations about prions.

Nor should you be. It just doesn't pass the sniff test that something so ubiquitous as these folded proteins should suddenly cause a new degenerative disease with such marked and significant symptoms never before documented in human history. Further, that it would be transmissible in the manner suggested doesn't strike me as quite right either.

OTOH, that organophosphate pesticides, some of which are known neurotoxins, might have delayed, second order combinatorial effects with background trace minerals is indeed possible and would certainly escape normal screening during product qualification.