Free Republic
Browse · Search
General/Chat
Topics · Post Article

To: TexasGator
"Multiple laboratory studies now confirm that Pfizer’s COVID-19 mRNA vaccine is heavily contaminated with plasmid DNA."

"Nutty conspiracy BUMP" ?

Seriously shallow analysis. Ridicule....a white cane to thrash anyone presenting "scary" facts.

28 posted on 04/02/2024 7:27:45 AM PDT by Pete from Shawnee Mission
[ Post Reply | Private Reply | To 4 | View Replies ]


To: Pete from Shawnee Mission
2010 Article on DNA vaccines. This is not specific to covid.

FDA Guidance on Prophylactic DNA Vaccines: Analysis and Recommendations

(Snip) 3.4) Plasmid Integration issues

DNA is considered a contaminant of “conventional” (non-DNA) vaccines. Manufacturers typically minimize or remove extraneous DNA during the production process to minimize human exposure to potentially injurious material. Not surprisingly, concerns that plasmid DNA might integrate into the host genome, increasing the likelihood of malignant transformation, genomic instability, or cell growth dysregulation were raised when DNA vaccines were first proposed for clinical use [31;36;41]. Based on advice from the Vaccine's Advisory Committee, the FDA set guidelines designed to insure that the frequency of plasmid integration would be substantially lower than the spontaneous mutation rate [42].

For novel plasmids or methods of formulation and delivery, integration studies would be required when plasmid persists at levels exceeding 10,000 copies per ug of host DNA. This recommendation reflects the expectation that only a tiny fraction of persisting plasmid will integrate into the host genome, regardless of the method of delivery [45].

In evaluating the potential harm of plasmid integration, it should be noted that the risk of introducing plasmids with strong regulatory regions into the host genome far exceeds that associated with random point mutations [43;50]. Moreover, the technology used to detect plasmid persistence does not examine the frequency with which short fragments of plasmid integrate. In this context, sections of DNA as short as 7 bp can affect rates of integration or recombination.

200,000 billion per ? of host DNA. Can't say, but sounds like they used a lot of "Hopium" in the manufacture of the covid "Vaccines". "Don't worry, trust us...yah....it will be all right!"

33 posted on 04/02/2024 7:57:41 AM PDT by Pete from Shawnee Mission
[ Post Reply | Private Reply | To 28 | View Replies ]

Free Republic
Browse · Search
General/Chat
Topics · Post Article


FreeRepublic, LLC, PO BOX 9771, FRESNO, CA 93794
FreeRepublic.com is powered by software copyright 2000-2008 John Robinson