[ConservativeMind]

Folks, the study used the drug cholestyramine, which sequesters bile and forces it out in a bowel movement. This drug has some side effects, but it seems to primarily work in the intestine, but apparently still gets somewhat absorbed. This absorption appears to hurt the liver’s ability to form new bile from cholesterol, according to a study I found on this drug and an alternative option.

PFAS wind up in bile, and bile is excreted by the gall bladder to breakdown fats. This drug lowers cholesterol because a lot of cholesterol is needed to make the bile. The drug causes bile to leave the body the next time you go to the bathroom.

Normally, the body is extremely efficient at “saving” bile, with as much as 95% of bile being reabsorbed for reuse, as I recall from my reading. A drug like cholestyramine stops this cycle. So the LDL and PFAS go into the toilet.

However, there is a perfectly safe bile sequestrant that people are heavily encouraged to use, to get rid of cholesterol, as well. It is called “psyllium fiber.” Psyllium also does not cause our liver to have problems making more bile from cholesterol, like cholestyramine appears to do, as serum bile acids stay elevated.

I will post the study that compares these two bile sequestrants in humans.

[ConservativeMind]

Psyllium Fiber Protects Against Colitis Via Activation of Bile Acid Sensor Farnesoid X Receptor

https://ncbi.nlm.nih.gov/pmc/articles/PMC10148163/

The study found that cholestyramine further hurt colitis patients, while psyllium helped minimize issues.

[ConservativeMind]

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[Paladin2]

Is mRNA a forever chemical?

Asking for [I AM SCIENCE] Fauxcy.

[Track9]

Bump. Thanks for the psyllium fiber info.

[ConservativeMind]

To best address cholesterol with psyllium, you need to take it about 20 minutes before eating fats (or a meal).

[sonova]

A question for someone more knowledgeable: If these compounds never break down, how do they cause harm to living things? They are only ingested in tiny amounts..

[Java4Jay]

Ping

[DannyTN]

I’ve spent a lifetime collecting forever chemicals.

Seems a shame to get rid of them now.