I recently purchased a Hematology med school textbook to understand this better. The more I study, the more complicated it gets due to the interactions between the various systems in the body.
I then purchased a new Endocrinology textbook to better understand the interactions with the clotting factors in the blood.
It’s very humbling as the body of knowledge it so great that scratching the surface opens Pandora’s Box.
Here is a good introductory article:
Many of these factors work both directions and can cause both clotting or hemmorages.
Von Willebrand factor is a blood glycoprotein that promotes hemostasis, specifically, platelet adhesion. It is deficient and/or defective in von Willebrand disease and is involved in many other diseases, including thrombotic thrombocytopenic purpura, Heyde’s syndrome, and possibly hemolytic–uremic syndrome.
Having factor V Leiden means that you have a greater chance of developing a dangerous blood clot in your legs (DVT) or lungs (PE). It occurs in 5% of people of European descent. Estrogen levels in the body influence this factor.
Prothrombin G20210A mutation (also called factor II mutation), which occurs in 2% of the population.
Estrogens have many different effects on the coagulation system. These include increases in the levels of procoagulant factors VII, X, XII, and XIII and reductions in the anticoagulant factors protein S and antithrombin.
Did any Cliff Notes come with that book?