Posted on 12/24/2023 7:29:59 PM PST by ConservativeMind
New research indicates that higher doses of topical corticosteroids, which are commonly used to treat inflammatory skin conditions, are linked with elevated risks of osteoporosis and bone fractures associated with osteoporosis. The findings are based on information from the Taiwan National Health Insurance Research Database.
Investigators selected 129,682 osteoporosis cases and 34,999 major osteoporotic fracture (MOF) cases and matched them with 518,728 and 139,996 controls (without osteoporosis or MOF) by sex and age.
The team found clear dose–response relationships between long-term use of topical corticosteroids and osteoporosis and MOF. For example, compared with no doses, low, medium, and high cumulative of doses topical corticosteroids were associated with 1.22-, 1.26-, and 1.34-times higher odds of developing osteoporosis over five years.
These respective doses were linked with 1.12-, 1.19-, and 1.29-times higher odds of experiencing MOF. Women had higher risks of osteoporosis and MOF than men. Also, younger people (< 50 years) had a higher risk of osteoporosis compared with other age groups.
"This study emphasizes that using topical corticosteroids to treat inflammatory skin conditions should be done very carefully and clinicians should be aware of these potential side effects," said corresponding author Chia-Yu Chu, MD Ph.D.
(Excerpt) Read more at medicalxpress.com ...
Minimize them, or treat your conditions in a different way, if bone density is a concern.
Steroids have always been the first option given to me and I have always rejected it. Low dose naltrexone cleared my psoriasis but I didn’t have it all over my body. There is a new expensive vitamin d drug that might work.
This isn’t really that surprising since most of us know about the negative side effects of medical steroids in general, like Prednisone.
I’ve used steroid creams for most of my life but have always tried to keep it to most minimum I can.
Steroids are a medical wonder when needed but as they say, there’s no free lunch. We pay in other ways. Weight gain is probably the most common side effect.
Prednisone was prescribed to me for UC (ulcerative colitis) and it worked great for a little while but it didn’t treat the cause that I now believe was me developing a sensitivity to the chlorine or other similar chemical used to treat tap water. Once I started filtering all the water I drink, it cleared up. Apparently I’m not so sensitive to it that just taking a shower causes skin irritation.
I think this sensitivity started when I had a hot tub 30 years ago or so. I believe I put too much bromine in it one time and it caused the sensitivity. I was probably prone to it. I have heard that it only takes one time. I stopped using the hot tub and was in another one maybe 15 years later that was a salt water tub but of course tap water with chlorine is also in it and I got the same asthma type reaction once the bubbles were turned on.
This, coupled with your other post on covid/probiotics, is ironic.
When researchers figure out why that is, we might actually see some developments in ‘modern medicine’.
But I seriously doubt that I’ll live to see said developments...
I, too have UC. Also Sarcoidosis. I’m already on two immunosuppressants because I had liver transplant surgery in 2021. I am now having issues with skin lesions and itching. I had them before the surgery, but not this bad.
I have an appointment to see a dermatologist next month, and hopefully get a handle on this. I’m wondering if I have eczema or psoriasis. Got some joint pain too. It could be age (I’m 69), but I’m hoping they can help me with this.
I’m a fan of LDN also.
A lot of people slather them on when they are effective in small doses - the size of a BB can be used on 2-4 sq inches of rash and do just as much good as smearing a large quantity on.
I use barely a drop and the condition goes away after a single application. Triamcynalone acetinide is a miracle drug.
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