Posted on 11/09/2023 10:04:27 PM PST by ConservativeMind
A study suggests metformin is a drug that could prevent the progression of prostate cancer, but only for tumors with low levels of NKX3.1, which are more likely to develop into aggressive cancers.
The researchers found metformin restores cancer-fighting mitochondrial activity that is lost when NKX3.1 levels are low, prevents prostate cancer progression in mice, and is associated with better survival in patients with low-NKX3.1 tumors but not high-NKX3.1 tumors.
Papachristodoulou found that when prostate cells are under oxidative stress (as happens during prostate cancer development), NKX3.1 moves into the cells' mitochrondria to reduce stress and protect the cells. If NKX3.1 levels are low, less protection is available, and prostate cells are more likely to turn malignant.
The researchers gave metformin to low-NKX3.1 mice that tend to develop prostate cancer.
Papachristodoulou says, "With metformin, we were able to stop further progression of the cancer."
The researchers then looked at human prostate cancer cells and tissues, confirming that metformin works on the same mitochondrial processes in people and prevents further cancerous changes.
Finally, the researchers retrospectively examined the effect of metformin in two groups of men who had been treated for prostate cancer. (Many men in both groups took metformin for their diabetes.)
After measuring NKX3.1 levels in tissue samples from the patients, researchers found that metformin only benefited patients with low NKX3.1 levels and mitochondrial impairment. Remarkably, among men with low NKX3.1 cancers under active surveillance, those taking metformin (three out of three) had their cancers downgraded during the surveillance period, while three out of four patients who did not take metformin had their cancers upgraded.
NKX3.1 levels are not typically measured in men newly diagnosed with prostate cancer, but based on the two cohorts examined, about 50% to 60% of patients may have low-expressing NKX3.1 tumors.
(Excerpt) Read more at medicalxpress.com ...
It looks like we men have over a 50% chance of having our prostate cancer be partly treatable with metformin.
Although the tests worked with mice and human tissues, the kicker was the human use, as stated in the last two paragraphs, above.
Didn’t they take a brand of Metformin off the market because it contained carcinogenic particles? My sister-in-law has been on it for years, and she’s always suffered from stomach cramps and diarrhea with it. It’s one of the known side-effects. I was on it briefly many years ago, and had the same problem But hey, if it can help you with prostate cancer, you can forget about the long list of side effects, right?
The inexpensive magical Metformin strikes again!
So when will it suffer the political fate of hydroxychloroquine?
Yeah, I believe it’s known for those side-effects.
Metformin seems to work for my genetic lineage. But the dosage has been minimal. The dietary approach is best if possible.
I wonder if any tests have ever been conducted with Berberine which has very similar effects as Metformin but has less undesirable side effects.
Great info, thanks for posting.
I read your posts more than I do the journals now :-)
There was one brand of metformin that was removed from the market a number of years ago. The issue resolved with a few months.
This has been known for at least a decade.
I used to take Metformin for my diabetes. Horrible stuff. Gave me acid reflux that tasted like industrial floor cleaner. Happy was the day that I could go on injections and quit taking it.
Metformin is a good drug, but a combination of IP6 and curcumin is likely even better.
What’s IP6?
https://www.lewrockwell.com/2005/06/bill-sardi/the-overlooked-cancer-cure-from-japan/
http://ip-6.net/files/77513690.pdf
The public needs to get this through their thick skulls. Cancer is NOT a genetic disease. It is a disease of cellular energy. Metformin proves it.
Change what you do and how you live.
I have looked at and read a fair bit of the three links at comment #13. One of the articles referred to how ip-6 increases the rate of natural cell death (apoptosis) in cancerous tissues. A year ago I read that Astaxanthin increased the rate of apoptosis in cancer tissues, but slowed it down in normal tissues. Along with other more common nutrients, I had my partner with prostate cancer and my brother with metastatic liver cancer add this to their daily supplements. My partner’s prostate cancer seems completely gone with a PSA score of 0.001. My brother’s liver metastases areas were shrinking and the doctor was talking about going in an removing some of them. Then he took his fourth Covid booster and his cancer immediately got much worse. He had also run out of Astaxanthin. He now has progressed through two increasingly severe chemo, and is feeling miserable all the time. I recently sent him a renewal of his missing supplements, and hope to see some improvement. I will also be sending him prints of some of this ip-6 material to show his oncologist.
+1
What in your experience is the dose of astaxanthin that is effective against cancer?
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