Posted on 11/04/2023 9:15:34 PM PDT by ConservativeMind
A study reveals that the use of doxycycline may help protect against Clostridioides difficile (C. diff) infection for some patients with pneumonia.
Specifically, study authors found that for hospitalized patients with community-acquired pneumonia who had experienced C. diff infections in the prior year, the use of doxycycline, instead of the more commonly used azithromycin, reduced the development of new C. diff infections by 45%.
More than a third of patients who suffer a C. diff infection will go on to have another in the future.
For patients who are admitted to a hospital with pneumonia, clinical guidelines typically recommend the use of azithromycin, which penetrates the lung tissue and can successfully treat Legionella pneumonia as well as more common types of pneumonia. While doxycycline should not be used to treat Legionella pneumonia, it can be effective against other types of pneumonia. In addition, doxycycline has optimal absorption in the upper gastrointestinal tract with minimal impact on the gut microbiome, which could account for the reduced risk of C. diff infection.
In this retrospective study, researchers analyzed outcomes of 156,107 patients treated for pneumonia in Veterans Affairs Hospitals between January 2009 and August 2022.
Patients diagnosed with Legionella pneumonia or viral pneumonia were excluded. Any patient who was diagnosed with a C. diff infection within 30 days of antibiotic treatment was presumed to have antibiotic-associated C. diff.
As expected, based on clinical guidelines, most patients were treated with azithromycin (87%) while a small proportion received doxycycline (13%). Overall, less than 1% of patients developed C. diff infections, but among patients who had experienced a C. diff infection in the year before their pneumonia diagnosis, 12% developed a new C. diff infection associated with the antibiotic treatment.
(Excerpt) Read more at medicalxpress.com ...
Good news for Doxycyclene but it put me in the hospital with heart attack symptoms. Turned out there was no heart connection but I don’t want it again.
For the record I reject the proposal by Lawson and Rainey (2015) to restrict the genus Clostridium to Clostridium butyricum.
https://youtu.be/RBmJGJ-CpHM?si=gAo8PnnjcNP3nNiY
📌
Gotta get my pneumonia shot….
Doxycycline only reduced the risk of relapse in patients with previous C. difficile .
For first episodes azithromycin and doxycycline were equal.
Anything that stops of C-diff is a godsend.
I have a close relative who died from C. diff.
Horrible stuff. My mother had it several times while we were her caregivers. Went to the hospital each time.
I developed C. Diff after extended use of AMOX-CLAV for a sinus infection and a dental abscess.
Now I have an ear infection. I’m being treated with doxycycline so I hope it prevents another bout with C Diff. By the way, I had 2 Covid shots plus the booster. Since then, it’s been one infection after another. I’ve never had an ear infection in my life until a couple of weeks ago.
Never again will I take another COVID booster.
I did get a good heart workup out of it, everything up to just before catheterization and got a no problems report which is a good thing.
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