I have single gun safes, that have anchor cables. I loop the cable around the frame of the passenger seat. The safe is hidden under the passenger seat and unless they want to attempt to rip the entire seat out, they are not getting the safe.
Without leaving the drivers seat, I can reach back and open the safe and have access in seconds, without having to look. Guns are store with the chamber locked open, safety on, and a full magazine loaded. With one finger I can then chamber a round and take the safety off.
Why in the world would you store your pistol with the chamber locked open and safety on?! I carry my Glock 23 on my person with one in the chamber. That’s the only way to carry. If I need to store it in my vehicle because I’m entering a prohibited area I leave it in Condition 1 as I store it.