However, there is an important caveat regarding the SV40 sequences in the Pfizer/BioNTech and Moderna plasmids that is rarely if ever mentioned in the current discussions, which is that the primary mechanism by which SV40 drives development of solid tumors (sarcomas) is the “Large T antigen” protein which the virus produces. The DNA sequences for this protein are NOT present in either of these plasmids.
I’m not qualified to comment on that.
It is not my field.