Posted on 10/18/2023 9:07:15 PM PDT by ConservativeMind
Researchers have discovered the link between the gut microbiota and Alzheimer's disease. For the first time, researchers have found that Alzheimer's symptoms can be transferred to a healthy young organism via the gut microbiota, confirming its role in the disease.
The study supports the emergence of the gut microbiome as a key target for investigation in Alzheimer's disease due to its particular susceptibility to lifestyle and environmental influence.
The study shows that that the memory impairments in people with Alzheimer's could be transferred to young animals through transplant of gut microbiota.
Alzheimer's patients had a higher abundance of inflammation-promoting bacteria in fecal samples, and these changes were directly associated with their cognitive status.
Professor Yvonne Nolan said, "The memory tests we investigated rely on the growth of new nerve cells in the hippocampus region of the brain. We saw that animals with gut bacteria from people with Alzheimer's produced fewer new nerve cells and had impaired memory."
"People with Alzheimer's are typically diagnosed at or after the onset of cognitive symptoms, which may be too late, at least for current therapeutic approaches. Understanding the role of gut microbes during prodromal—or early stage- dementia, before the potential onset of symptoms may open avenues for new therapy development, or even individualized intervention," said Professor Nolan.
Alzheimer's is the most common cause of dementia, a general term for memory loss and other cognitive abilities serious enough to interfere with daily life. As our population ages, one in three people born today are likely to develop Alzheimer's. Scientists in UCC are working to develop strategies to promote healthy brain aging and advance treatments for Alzheimer's by exploring how the gut microbiota respond to lifestyle influences like diet and exercise.
(Excerpt) Read more at medicalxpress.com ...
We could possibly adjust this by diet, if so.
While Alzheimer’s affects most older people, it’s a fact that leftists get Alzheimer’s about twice as often as conservatives. Although, having a voting disorder is more a symptom than a cause.
The Leftnick leaders know their electorate is suffering from Alzheimers and have become foot-dragging zombies. In order to help them be reliable voters, they fix their ballots so they get their vote right. Now with vote-counting machines, all they have to do is fix the machines. Alzheimer’s has been cured.
/sarc.
So, what probiotics do we take? Do they know yet?
Soluble fiber, fewer simple sugars/carbs, and more taurine (meat), seem to be indicated, which would shift the existing populations and increase a key amino acid.
The results of the present study confirm that Alzheimer's disease is characterized by systemic and gut inflammation.29,93 Moreover, the decrease in abundance of the phyla Firmicutes and the increase in Bacteroidetes observed in Alzheimer's patients compared with age-matched cognitively healthy subjects is in line with several findings in US35 and Chinese populations.34,36 At genera level and in agreement with our findings, reduced abundance of Clostridium sensu stricto 1 is associated with adverse outcomes in Alzheimer's disease.33,35 The parabiont Desulfovibrio has also been found to be enriched in other Alzheimer's cohorts33,94 and is associated with reduced caecal levels of SCFAs and with inflammation in mice.95 As previously reported, we found a lower proportion of bacteria with the potential to synthetize butyrate,33,94 a microbial metabolite negatively associated with cortical amyloid accumulation.96 Furthermore, we confirmed reduced abundance of the genus Coprococcus in Alzheimer's disease,33 which is associated with amyloid accumulation.97 When interpreting microbiota data however, it is important to keep in mind that results may be influenced by geography,98 the inclusion criteria of study participants and methodological difference (i.e. sample collection and processing, freeze-thaw, storage methods, different bioinformatics pipelines).99,100 Not surprisingly, human faeces from different donors engrafted in rats at different rates. Notwithstanding, transfer of faecal microbiota from cognitively healthy subjects to rats resulted in the taxa diversity remaining relatively stable over time, whereas after transfer from Alzheimer's donors, there was a greater alteration in taxa between 10 and 59 days post-FMT. Notably, one of the genera that was increased at Day 59 post Alzheimer's-FMT compared to Day 10 was Desulfovibrio, a genus that was also significantly enriched in Alzheimer's participants.
Notably, however, the free amino acid taurine was decreased in the hippocampus of Alzheimer's-FMT rats. Taurine administration has repeatedly been shown to increase hippocampal neural stem and progenitor cell proliferation, survival and neurogenesis both in vivo and in vitro.88 Given its blood–brain barrier permeability,126 it is conceivable that some of the observed effects of Alzheimer's-FMT on AHN could partly be mediated via taurine.
Thank you.
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