Posted on 10/12/2023 9:42:16 AM PDT by ConservativeMind
Researchers are testing a drug against obesity and diabetes, and now a team reports that substance has a beneficial effect on mice with experimental lung cancer.
The substance is the short-chain fatty acid propionate, which is naturally produced by bacteria in our gut. This new research study shows that treating mice with lung cancer with propionate can reduce the occurrence of metastases.
The study also demonstrates a role for propionate in increasing the effectiveness of Cisplatin, a commonly used drug for lung cancer patients.
One of these programs is called EMT (epithelial-mesenchymal transition), which existed even when we were still embryos. Its purpose was to ensure that newly formed cells could move to the right places and differentiate to different organs.
The dataset, originating from nearly 1,500 patients, provided the researchers with metabolic and genetic data. Here, they discovered a correlation between genetic signs of cellular propionate and the effectiveness of the EMT program: an activation of propionate-related genes coincided with low EMT efficiency. EMT efficiency is significant in allowing cancer cells to spread through the EMT program: the more efficient it is, the better it is at helping cancer cells move around the body.
The second part of the evidence in their study is the results from an experiment with two groups of mice in which they have induced lung cancer. One group received propionate in their drinking water (group A), while the other group did not (group B).
When the cancer-stricken mice died naturally after a month or two, they were examined for metastases. In group A, 20 percent of the mice had developed metastases, while in group B, 60 percent had metastases.
"At the moment, there is no medication that can block the EMT program and thus prevent the formation of metastases," says Paolo Ceppi.
(Excerpt) Read more at medicalxpress.com ...
My wife and I get ours from tasty Keto breads and bagels, and some occasional whole husk psyllium.
Friend of mine has Lung cancer, stage 4 I think. Is it possible to get this trial anywhere ?
I have lung cancer right now. Reading this with much interest.
Here is a link to the full article in pdf format.
https://www.embopress.org/doi/epdf/10.15252/emmm.202317836
Yep- i use “Equate” Soluble fiber which is much cheaper than Metamucil- use it every day- 2 heaping spoonfuls a day- not sure how much it is- I’ve tried keto breads before- blech- but the fiber is easy to take-
Here’s hoping it gets under control for you-
I went through a scare awhile back- I got pneumonia once, had spots on the lung after the pneumonia cleared- doc though it was cancer- and was scheduled for 1/3 of lung to be removed and was like 3 days aWay from the operation- i got nervous, asked for a biopsi first- they took several and didn’t see cancer- but didn’t know what the cause for the spots were- they eventually subsided- Still don’t know what it was- did eventually develop COPD and emphysema- both somewhat mild- don’t need oxygen=- but limits what i can do- but very very thankful the spots were not cancer-
Yours could have been sarcoidosis.
I’ve had the biopsy and Pet Scan confirm it.
Going under the knife in a week.
I have the best thoracic surgeon and he’s doing a minimally invasive laproscopic lobectomy. He actually invented the technique in 1999. Should be home in two days.
🙏
I Pray everythign Goes well and speedy recovery- the laproscopic will be much easier- such a great way to operate- I’ve had several, and recovery was much easier thankfully-
2 tablespoons is about 5g of soluble fiber.
I would suggest that at Stage 4, unusual therapy options could be entertained, if doctors don't have workable options.
I will say that fenbendazole may be one such approach, if all other options haven't worked. It worked for Joe Tippens, but he had Small Cell Lung Cancer. Do note that he is a study of “one.”
He's been multiple time doctor-reviewed, cancer free, for years.
There are no formal studies on this in humans, but if I had no other options, I'd consider it.
I’ll suggest that to her. Thank you.
🙏
As a cancer patient, these crazy non-medical interventions are a good way to die. Ask Steve Jobs -- a man who had everything but not enough sense to seek out the best cancer medical diagnosis and expert opinion possible.
I was diagnosed at a large regional hospital by so-called experts. I sought a second opinion at the top cancer hospital in the country, where they have the most advanced diagnostic equipment and world-class research right on site.
It saved my life.
There are less than 10 of these top centers in the country.
Small Cell is serious. Very serious.
Oh she’s already done the chemo, the radiation. It’s really a shame. She says she just can’t do that anymore.
That's sad.
I go to MD Anderson every six months for a follow-up check. Been going since May 2014. I always talk with as many people/patients as I can when I go. My top question of them is, what brought them there?
I would say that 75% of them say that the diagnosis, which is a critical first step, was either not correct or sub-par, which leads to a treatment that may be the same (or worse).
By the way, that was my personal experience at a so-called large regional center, too, before I first went to MDA.
Cancer is not a simple disease. While I have a rare form of blood cancer, there are unique characteristics that can be found in state-of-the-art centers that drive the type of treatment. Sometimes, in a top center, the onc doc can confer with the researchers in-house with novel options.
Once you start down the path with treatment, it is difficult to change from that type of treatment. That subpar treatment plan can impact your next treatment -- if you make it.
That's why I tell all my friends that will listen who have ANY form of cancer to take a little time and seek a second opinion from one of the top 10 centers.
It may just be the difference between living a good life and not.
thnaks, so probably around 6-7 as they are heaping soup spoonfuls-
Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.