It fits.
I was Googling here and there and found this very detailed account of low cost, successful, outpatient treatment of people with Covid. Since I had just bought some apple flavored Ivermectin in a farm supply store, I wanted more details about using it for my own treatment. Bottom Line: It is far better to use it in combination, as solo use can promote development of resistant organisms. This article lists the doses given to these 50 years plus, very sick out-patients. None ever hospitalized. See TREATMENT near end.
https://www.medrxiv.org/content/10.1101/2021.07.06.21259924v1.full-text (Ivermectin-IVM study) (doses follow discussion)
DISCUSSION SIMPLIFIED: (Key points capitalized)
Regarding strategies in the development of combination therapies, intracellular coronavirus replication REQUIRES SEVERAL ACTIVE DRUGS to inhibit viral replication. IVM, doxycycline and zinc all individually inhibit coronavirus replication and, although there are other candidates, we have proposed the above combination based on efficacy, component safety profiles, inexpensive nature, and lack of drug-drug interaction. The combination of IVM and Doxycycline also appears to overcome the need for high doses of IVM. Further, given that zinc plays a key role in antiviral activity [34536] it would combine well with the ionophores (IVM and doxycycline) to increase its intracellular concentration and expedite viral clearance [37]. The combination of zinc with IVM and doxycycline has no reported interactions. Additionally, Each of these drugs has a low adverse side effects profile and no QT prolongation (heart issue) as reported with azithromycin.
Overall, based on the current literature, a 10-day combination therapy of IVM, doxycycline and zinc will not only improve symptoms [6,7] but also accelerate recovery from COVID-19. We have chosen a safe IVM dosage approved for parasites of 36mg over 10 days, and this dose has been shown to be both effective and safe in COVID-19 treatments [38]. The staggered IVM dosage over 10 days is proposed based on the half-life clearance of the drug in plasma (up to 66 hrs.)[39]. The proposed duration would allow constant availability of adequate plasma level IVM to facilitate zinc entry into the cells. Hence, the above rationale explains why some publications have already shown that IVM alone is not adequate to cure COVID-19 [6,18,19] while a multidrug regimen is likely to be more efficacious [40].
A weakness of this study is the lack of a concomitantly enrolled control arm. However, given the potential FATAL OUTCOMES, Tess Lawrie et al. indicated [41] ‘it is no longer ethical to approve the use of a control arm as so many profoundly ill patients in the control arm would die’, as did our two subjects who declined treatment [42]. Institutional Review Boards should now include the provision to include available synthetic arms and REJECT TRIALS that include in a COVID-19 trial a control arm as published by Lawrie[41].
This study builds on an extensive literature, to provide a practical inexpensive, safe, readily available and highly effective TRIPLE THERAPY aiming to prevent resistance and one that can confidently be used as a routine treatment for outpatient COVID-19. [It also included useful amounts of Vitamins C and D3.]
TREATMENT (Cure was considered an SpO2 (blood oxygen above 95%)
Treatment began as soon as practical, within 72 hrs. of patients presenting to Ventura Clinical Trials. Treatment was defined as ‘IVM Combination Therapy’ (ICT) and consisted of TEN DAYS of oral: Doxycycline (100mg twice a day), IVM (12mg on day 1, day 4, and day 8), Zinc (25mg twice a day), Vitamin D3 (1500 IU twice a day) and Vitamin C (1500mg twice a day). ICT was given daily for ten days only. (It was found good IVM blood levels lasted 60+ hours.)
Two patients (#10 and #23) received an initial treatment on day one of 36 mg IVM (rather than 12mg) due to particularly low SpO2 or expected clinical need.
What a relief. Now I know how to take my Ivermectin. The farm store lady insisted it was only to be used for horses, so I will have to figure how much of the paste equals the recommended mgs. per dose.