Posted on 10/02/2023 6:35:32 PM PDT by ConservativeMind
Colorectal cancer (CRC) with synchronous peritoneal metastases (SPM) is a challenging disease to treat with a relatively poor prognosis. However, recent advances in treatment strategies have led to improved outcomes for patients with SPM.
The optimal treatment approach for CRC with SPM remains controversial. A growing body of evidence suggests that comprehensive treatment, including cytoreductive surgery (CRS), chemotherapy, and hyperthermic intraperitoneal chemotherapy (HIPEC), may improve patient outcomes.
A recent study evaluated the treatment strategies and outcomes of patients with CRC with SPM. The study included a large sample of patients and the findings suggest that comprehensive treatment was associated with a significantly improved prognosis.
Specifically, patients who underwent CRS, chemotherapy, and HIPEC had a median overall survival of 29 months, compared to 14 months for patients who received less aggressive treatment. The study also found that complete cytoreductive surgery (CC-0), in which all visible cancer is removed during CRS, was an independent predictor of improved survival.
The findings of this study are significant because they provide further evidence to support the use of comprehensive treatment for patients with CRC with SPM. The study also highlights the importance of CC-0 in achieving long-term survival benefits.
However, it is important to note that this study was observational.
Most studies on the treatment and prognosis of patients with colorectal SPM have been conducted in Europe and North America, with limited data available from China. The optimal treatment approach for CRC with SPM remains controversial.
The researchers also highlighted that the National Comprehensive Cancer Network (NCCN) guideline is conservative regarding CRS plus HIPEC, and clinicians still tend to favor palliative care for patients with CRC with peritoneal metastases.
Overall, the findings suggest patients with CRC with SPM who receive integrated treatment have better prognoses. Specifically, CC-0 should be considered to achieve long-term survival benefits.
(Excerpt) Read more at medicalxpress.com ...
This was an observation, so not fully capable of proving this set of therapies addresses it, but it looks potentially possible.
Rectum? D*mn near killed ‘em!
The HIPEC procedure is very risky. Once they’ve opened you up, they bathe the abdomen in chemotherapy and you stay under anesthesia and on the table for an extended period (close to 12 hours). The recovery becomes much more prolonged and difficult. Our oncologist wanted this procedure and surgeon was willing to do it but thankfully, my husband did his research and rejected it. We proceeded without it and I am happy to say that his treatment was a success and he is cancer free. As with everything medical, you must do your own research.
As with everything medical, you must do your own research.
Amen. A little knowledge is empowering. While I have not been in this particular situation (not yet, anyway), I have had enough interactions over the years to know that there are good doctors, there are great doctors, and there are know-it-alls who think that they know better than you do. I’ve had them all.
Thank God the percentage of know-it-alls has been small.
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