Posted on 09/18/2023 8:20:10 PM PDT by ConservativeMind
Kidney stones are a common condition that affects millions of people worldwide. While genetics and various other factors can contribute to kidney stones, dietary components play a significant role in their formation. Previous research has isolated specific dietary culprits such as high oxalate or calcium intake. However, understanding of the effects of specific dietary components on stone formation remains limited.
In this study, researchers used male CD-1 mice to explore the potential correlation between dietary intake and KS. Initially, the size of urinary sediment particles was analyzed in mice that were administered with cholesterol and fruit tannins by gavage.
The results showed that CT-mice or ECT mice had significantly larger urine sediment particles, and crystals larger than 20 μm were clearly visible in their urine compared with the other subject groups. Furthermore, ethylene glycol, a known promoter of oxalate excretion in the kidney, was identified to enhance urinary stone formation. Subsequently, crystallographic analysis of kidney tissues from CT-mice revealed distinct crystalline substances, especially prominent in the renal papilla of ECT-mice.
These crystal grains were composed of two types: filter cake shaped grain and the multiple nuclei grain. Paraffin embedding and HE staining elucidated inflammatory responses and vascular stasis around the kidney tubules with crystalline deposits in ECT-mice. Micro-stones, visible under a polarizing microscope, were identified in the kidneys of ECT-mice.
Remarkably, tannin and cholesterol deposits in the kidney were highlighted using immunofluorescence with antibodies against apple tannins and the Filipin-fluorescence detection method, respectively. Laser-assisted visualization of crystal deposits indicated their association with tannin deposits or co-deposition with cholesterol.
In summary, this study underscores the critical synergistic role of cholesterol and tannins in KS formation. This research holds significant value for nutritional guidelines and public health recommendations, emphasizing a holistic dietary approach to prevent kidney stone-related complications in the future.
(Excerpt) Read more at medicalxpress.com ...
ECT = Ethylene glycol, cholesterol and apple tannins CT = Cholesterol and apple tannins
It appears dietary cholesterol with apple tannins, taken at the same time for a period of three days, caused a solute supersaturation of the two to occur, making a lot of crystals which then make kidney stones.
The paper describes high fat/cholesterol foods with high tannin fruits as a combination to avoid for extended periods of time. It also says to drink lots of fluids, which could abate the issue.
So... ditch the McDonald’s apple slices with your Big Mac happy meal?
Or drink a lot of water.
And go easy on the ethylene glycol.
Most people run around dehydrated. More so than less so.
My dad got kidney stones as manager in his retail sales career. He hardly drank all day to cut down on bathroom trips, during the extremely long and busy day.
The elderly are really at risk of dehydration and sometimes just being dehydrated makes them appear to be suffering from other things instead of simply not drinking enough. My mom often doesnt drink enough and she has issues when she doesn’t drink enough during the day. They forget when the last time it was they drank something.
“And go easy on the ethylene glycol.”
I try.
So, an apple a day…doesn’t…?
B6 (in the morning) and magnesium = no kidney stones.
Was drinking 4-5 Diet Cokes a day. Urologist said to quit unless I wanted to keep having them. Haven’t had one since. They had to go through my back to get them out. Woke up with two catheters and I was like, WTF??
That would fundamentally freak me out, too.
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