Posted on 09/04/2023 6:02:44 PM PDT by ConservativeMind
Inorganic nitrate reduces contrast-induced nephropathy (CIN), improves renal outcomes and reduces cardiac events compared to placebo in patients at risk of renal injury undergoing coronary angiography for acute coronary syndrome, according to research.
CIN, also termed contrast associated-acute kidney injury, refers to a deterioration in renal function after contrast exposure and is a serious complication of coronary angiography.
Research has suggested that nitric oxide is deficient in CIN; therefore, strategies to replace nitric oxide might be of benefit.
The NITRATE-CIN trial examined the efficacy of inorganic nitrate for the prevention of CIN in patients with non-ST elevation acute coronary syndrome referred for invasive coronary angiography and at risk of CIN.
NITRATE-CIN was a double-blind, randomized, placebo-controlled trial. Patients were randomized in a 1:1 ratio to once daily potassium nitrate (12 mmol) or placebo (potassium chloride) capsules for 5 days.
The primary endpoint was the incidence of CIN (³0.3 mg/dl or ³26.5 mmol/L increase in creatinine within 48 hours or ³1.5 times within 1 week), as defined by the Kidney Disease Improving Global Outcomes (KDIGO) criteria for acute kidney injury. Secondary outcomes included renal function (eGFR) at 3 months, rates of procedural myocardial infarction and major adverse cardiac events (MACE) at 12 months.
Standard care for CIN prevention in both arms matched ESC recommendations (hydration before and after coronary angiography, use of low-osmolar contrast media).
Inorganic nitrate treatment significantly reduced CIN rates (9.1%) versus placebo (30.5%; p<0·001). This difference persisted after adjustment for baseline creatinine concentration and diabetes status (odds ratio [OR] 0.21; 95% confidence interval [CI] 0.13 to 0.34). Secondary outcomes were improved with inorganic nitrate, with lower rates of procedural myocardial infarction (2.7% vs. 12.5%; p=0.003), improved 3-month renal function (between group change in eGFR 5.17 [interquartile range 3.94-7.39]) and reduced 1-year MACE (9.1% vs. 18.1%; p=0.001) versus placebo.
(Excerpt) Read more at medicalxpress.com ...
Doing both might save nearly everyone’s kidneys.
And guess what has lots of nitrates. Bacon! Bacon is good for the heart. The more you know...
This is an interesting concept. I wonder if it would help with MRI contrast such as gadolinium.
The Drug Bank indicates that even in severely renal impaired patients Gadolinium should leave your body in less than a week.
It did not for me as proven by a urine workup.
If anyone here knows the Chuck Norris (you never know who is lurking) his wife should check her MDR1 gene. A defect in that gene may be why she had such a reaction to Gadolinium. When you have some of these defects it can cause a problem with these contrast agents. A normal dose overdosed me because the p glycoprotein action didn’t pump the toxin out.
The same might hold true for these other types of contrasts.
Definitely drink a lot of water to try to get it out of your body.
One thing I noticed is that activated charcoal seemed to help my symptoms. It has been shown to help the creatine issue. I just wish I had bombarded my system with activated charcoal (on a short term basis) once I noticed an issue.
The type of gadolinium contrast really matters.
ProHance is seemingly the best MRI gadolinium contrast out there.
I’m not immediately aware of what can help eliminate gadolinium. It is supposed to be inert, but several forms can break down and expose the gadolinium, making it more toxic.
“I’m not immediately aware of what can help eliminate gadolinium. It is supposed to be inert, but several forms can break down and expose the gadolinium, making it more toxic.”
This is exactly why I didnt use a chelation supplement like EDTA. They used Gadavist on me. There is such a thing as Gadolinium Deposition Disease but I can tell you from my experience that a toxicologist stated there were problems with that study and wasn’t convinced such a thing even exists.. My problem was clearly genetic with my body not operating properly but I suspect the problem that the wife of Chuck Norris had could be an issue for people who have to get a lot of MRIs.
Spirulina that people use for radiation might help with Imaging contrast agents. I use XR Shield by Life Extension now but who knows whether it really helps.
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