Posted on 08/27/2023 2:21:23 PM PDT by ConservativeMind
Urine levels of adenine, a metabolite produced in the kidney, are predictive and a causative biomarker of looming progressive kidney failure in patients with diabetes, a finding that could lead to earlier diagnosis and intervention, researchers reported.
The study results are significant because until now, the most important marker for kidney disease has been protein (or albumin) in the urine. Up to half of diabetes patients who develop kidney failure never have much protein in their urine. As 90% of patients with diabetes (more than 37 million patients in the U.S.) remain at increased risk despite low levels of albumin in their urine, this study has widespread consequences. It is the first study to identify these patients at an early stage by measuring this new causative marker in the urine.
The finding paves the way for clinic testing to determine—five to 10 years before kidney failure—that a patient is at risk, said Kumar Sharma, MD.
Importantly, the research team identified a small molecule that blocks the major pathway of endogenous adenine production in the body. This therapeutic drug reduced kidney adenine levels in mice with type 2 diabetes. "The drug protected against all the major aspects of diabetic kidney disease without affecting blood sugar," Sharma said. "The study is remarkable as it could pave the way to precision medicine for diabetic kidney disease at an early stage of the disease."
(Excerpt) Read more at medicalxpress.com ...
However, they found that Empagliflozin (Jardiance) basically attenuated the problem, seemingly keeping the kidneys safe.
Farxiga appears to be a similar drug but with a different active ingredient.
bkmk
Bump for reference
I just started jardiance. When I got on Medicare, I got a very good drug plan because of my diabetes. Jardiance is about 1000 a month. I paid 600 for the first month, which was my deductible, and 10 a month after that.
I use it with remarkable results. I was getting prepped for dialysis when I went on faziga and was stage 4. Now 3a. Expensive but the alternative for me rather than dialysis was cheaper but messy.
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