Researchers discover potential new prescription strategy for ischemic stroke (Omega-3 fat derivatives)

Medical Xpress / Louisiana State University / Cellular and Molecular Neurobiology ^ | June 6, 2023 | Madigan M. Reid et al

[ConservativeMind]

A study reports that the additive neuroprotection of a combination of two omega-3 fatty acid-derived signaling molecules is more effective in protecting brain cells and increasing recovery from stroke in an experimental model than a single drug.

The team examined the bioactivity of Neuroprotectin D1 (NPD1—discovered by the Bazan lab in 2003) combined with Resolvin D1 (RvD1) in experimental stroke. These two naturally occurring neuroprotective molecules in the brain derived from docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) called docosanoids have been shown to limit excessive inflammatory responses, regulate metabolism and immune cell functions, decrease the production of proinflammatory factors, and promote tissue repair and stability.

The scientists found that the combination therapy boosted the uptake of an anti-inflammatory stroke-associated gene by 123-fold, a gene that regulates new brain cell and blood vessel growth by 100-fold, and two markers of the stability of the brain cells that regulate brain development, maintenance of neuronal networks and injury repair by ten- and fivefold, respectively.

"We show that NPD1 + RvD1 remarkably improves neurological function and reduces lesion volume in acute ischemic stroke when administered promptly in moderate doses," adds Ludmila Belayev, MD.

"We also demonstrated a broad therapeutic window of neuroprotection with moderate doses of NPD1 + RvD1, such that treatment initiated even 6 hours after stroke onset is highly effective. This combinatorial therapy may promise future therapeutic development against ischemic stroke."

"The biological activity of NPD1 plus RvD1 is due to specific activation and modulation of signaling pathways associated with the immune system, inflammation, cell survival, and cell-cell interactions," concludes Dr. Bazan. "These findings provide a major conceptual advance of broad therapeutic relevance for cell survival, brain function and, particularly, stroke and neurodegenerative diseases."

[ConservativeMind]

Although these are derivative molecules from two Omega-3 fatty acids, we produce these converted forms in our brains from the original fats.

So get your EPA and DHA and at least a bit more of the benefit these molecules otherwise provide.

[ConservativeMind]

The “Take Charge Of Your Health” Ping List
This high volume ping list is for health articles and studies which describe something you or your doctor, when informed, may be able to immediately implement for your benefit.

Email me to get on either the “Common/Top Issues” (20 - 25% fewer pings) or “Everything” list.

[imabadboy99]

But big pharma can’t make money off omega 3 !!!! It’s not fair!!!! We need to ban vitamins !!! /s

[steve86]

Not ban them but make them prescription only.

[thinden]

Bttt