Obesity turning arthritic joint cells into pro-inflammation 'bad apples'

Medical Xpress / University of Birmingham / Clinical and Translational Medicine ^ | April 4, 2023 | Susanne N. Wijesinghe et al

[ConservativeMind]

Being overweight may be physically changing the environment within people's joints, as new research suggests that obesity is promoting pro-inflammatory conditions which worsen arthritis.

In a study, researchers have found that specific cells in the joint lining tissue (synovium) of patients with osteoarthritis are being changed due to factors associated with obesity.

Previous research has shown that fat tissue that has been metabolically altered by obesity releases proteins called cytokines and adipokines, which are known to promote inflammation around the body. The newly published study observed that in cells taken from biopsies of arthritic joints, obesity also changes the environment within the joint itself, leaving cells in the joint vulnerable to being 'turned' into those that promote inflammation.

Dr. Susanne Wijesinghe said, "We have seen that obesity can promote the kind of destructive inflammation in joints that goes far beyond what we might expect to see from wear and tear alone, even in non weight-bearing joints."

"Obesity is creating an environment in the body, which is negatively affecting cells called synovial fibroblasts, which are stem cells involved in regulating the lubricating fluid of the joints. The effect is that these cells get recoded into those that promote inflammation within the fluid around the joints. Then they begin to affect the whole joint, increasing secretion of chemicals such as CHI3L1 which degrade the joint and increase the progression of osteoarthritis."

Weight wasn't determined to be the driving factor for impacting the joint cells leading to greater inflammation, the research found.

The team of researchers used biopsy information from a range of joints. The results found that there were independent impacts of obesity on load bearing and non-load bearing joints, and that among the 16 patients with BMI of over 30, weight alone didn't account for the molecular changes in those joints.

[ConservativeMind]

Weight alone was not the driving factor, but the inflammation that typically come from it, was.

This seems to point back to the benefit of either an anti-inflammatory diet and/or exercise. Our fat is inflammatory, but, perhaps worse, is the rest of what we have happening that creates inflammation.

[ConservativeMind]

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[sauropod]

Bkmk for review.

[Delta 21]

So I thot being morbidly over weight was supposed to be promoted as healthy, sexy and “You go girl!”. Didnt these yahoos get the memo?

There is enough fat shaming in that article to call an emergency redaction before the uber-carbs read it and form some kind of retaliatory cancel mob. And I am also now a target as well, because I am a racist for noticing and commenting?