Posted on 03/22/2023 12:42:17 PM PDT by ConservativeMind
A recent study compared the gut microbiota and gut-derived metabolites between healthy controls and individuals with fatty liver. The results revealed that certain microbial metabolites are associated with liver fat content.
The fact that the gut microbiota associates with many diseases, has raised the hope that they could be used for diagnostic purposes. One of the progressing research fields is the analysis of gut-derived metabolites that are manufactured by the microbes from the food.
Fatty liver disease is the most common chronic liver disease world-wide, especially in individuals with obesity, and it predisposes to cardiovascular diseases. The recent study compared the gut microbiota and gut-derived metabolites between healthy controls and individuals with fatty liver.
The researchers found that individuals with fatty liver had, for instance, more degradation products of the amino acid leucine and histidine, as well as less of testosterone in their feces.
"These could be useful gut microbiota-derived biomarkers for diagnosing fatty liver disease," says Senior Lecturer Satu Pekkala. "We are currently analyzing new data to determine whether these biomarkers could also be used to identify fatty liver patients that can be treated with personalized diet."
The most interesting finding in the blood samples was that the individuals with fatty liver had higher levels of caffeine and its metabolites, even though both groups consumed the same amount of coffee.
A failure in caffeine metabolism can reflect lower activity of cytochrome enzymes in the liver. These enzymes are important degraders of drugs and nutrients, and therefore their role should be studied more to understand the importance of these enzymes and fatty liver in overall health.
(Excerpt) Read more at medicalxpress.com ...
On some things, that might be good, but on others, it can be bad.
We need our liver to function appropriately.
If you likely have a fatty liver, consider trimming back on caffeine hours early than you do, to get a better night’s sleep.
If you would like to get rid of your fatty liver, reducing body weight to 14% was shown to do it in one study I’m remembering, and from another study, Pantetheine was found to reverse fatty liver in six months in over half who took it, without losing the weight. I’ve previously posted that Japanese study.
I will tell you a test that may be the early sign if you can’t get insurance to pay for a fibroscan.
I was diagnosed with fatty liver. I had elevated LDH which continued for over a year with multiple tests. When my fatty liver mysteriously disappeared my LDH level came back down. The two may be entirely unrelated but it is something to look for...
Lactate dehydrogenase is what LDH stands for, for those who don’t know.
That is a reasonable marker. It is a good inflammatory diagnostic.
My LDH is just below the normal range. I also do not have a fatty liver, known from a scan.
Keep up the good work!
Intermittent fasting has been shown to reduce fatty liver. If I’m not mistaken the liver is one of the few organs capable of self-repair/regeneration.
The liver stores glucose or sugar for use as energy, when fasting the body uses up this stored energy in the liver, bloodstream, and muscles completely - and starts mobilizing stored body fat for energy. I can see how calorie restriction in general m, regardless of method, leading to significant weight loss would improve liver health dramatically.
Time-restricted eating, also known as intermittent fasting (IF), can reverse fatty liver disease.
If I didn’t know better I might think that IF can even balance the Federal budget deficit.
Well, I think going to a low-carbohydrate, low sugar diet with IF will do a lot to reduce the grocery budget. But certain foods and frequent eating have an addictive component, so some planning is needed.
Fecal transplants have cured people with Multiple Sclerosis. No Big Pharma profits, so don’t expect FDA approval any time soon.
I spelled “Pantethine” wrong in my first post. Sorry about that.
Here’s the study:
https://freerepublic.com/focus/f-chat/4008349/posts
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