I also have Factor V Leiden, so this actually concerns me a bit.
I have a friend with one gene Factor V Leiden. He had a miserable reaction to his first Moderna vaccine. He had a much worse reaction to his second Moderna vax. This was in early 2021 when my small city was having hearings on Covid and municipally supplied vaccines. I submitted testimony to the fact that Factor V and also Sickle Cell Trait and Disease (which affects Africn-Americans) were two blood conditions which might bear special attention. I suggested that at vaccine clinics, people with those conditions should be made aware of potential reactions and also be encouraged to stay more than 15 minutes to see if a bad reaction occurred after the shot. I also submitted an estimate as to how many thousands of the city residents might have those conditions. In addition I suggested that since around 2.5 times more Blacks were dying of Covid that it would be a good idea to encourage people to improve their immunity with Vitamin D3 capsules. I never saw any sign these advices were acted on by my local government.
Recently I saw titles of 2 articles on Factor V and the Covid issue, but unfortunately my computer jumped to another tab before I could copy the URLs for these articles. Perhaps someone else saw them and could send me the URLs.