Stereotactic body radiotherapy is an effective treatment for patients with lung neuroendocrine tumors

Medical Xpress / H. Lee Moffitt Cancer Ctr & Res Inst / Intl Jrnl of Radiation Oncology ^ | Feb. 3, 2023 | Daniel E. Oliver et al

[ConservativeMind]

Primary lung neuroendocrine tumors are very rare tumors that represent about 1-2% of all lung cancer cases. The common treatment for early stage lung neuroendocrine tumors is surgery, but that is not an option for all patients.

In a new article, Daniel Oliver, M.D. shows that stereotactic body radiotherapy, or SBRT, is an effective treatment for patients with early stage lung neuroendocrine tumors.

SBRT is a treatment approach that delivers high doses of radiation to precise areas of a tumor, minimizing damage to surrounding normal cells. Patients receiving SBRT often have less toxicity and side effects compared to treatment with conventional radiotherapy that is delivered in smaller doses each day over several weeks.

"SBRT is commonly used as a treatment for early stage non-small cell lung cancer, and our results show strong tumor control. This suggests that SBRT may also be effective for lung neuroendocrine tumors," said Oliver. "SBRT is increasingly being used to treat early stage lung neuroendocrine tumors."

Oliver and his team wanted to assess the efficacy and long-term outcomes of SBRT in patients with lung neuroendocrine tumors. They performed a retrospective analysis of 48 lung neuroendocrine tumors from 46 patients who were treated with SBRT from 11 institutions across the U.S. The researchers discovered that SBRT provided strong local/regional tumor control.

The three-, six- and nine-year local control rates with SBRT were 97%, 91% and 91% respectively, and only one regional recurrence occurred. The treatment was also well tolerated with only one case of SBRT-related toxicities reported, which was considered low-grade.

Results from the study are comparable to historical populations of lung neuroendocrine tumor patients who were treated with surgery, which is particularly notable given that many patients treated with SBRT typically have additional health conditions that can make treatment difficult and result in poorer outcomes.

[ConservativeMind]

An existing therapy can also be very successfully used on lung endocrine tumors.

[ConservativeMind]

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There is a Harvard Trained Doctor and a Triple board certified oncologist named Dr. Gil Lederman who has a weekly radio show in the New York Metro area talking about the cases he’s had with cancer patients using stereotactic radio surgery.

This is his website for those interested :

https://www.rsny.org/