Nearly 10 percent of psoriasis patients have high risk for liver fibrosis

Medical Xpress / HealthDay / Frontiers in Medicine ^ | Jan. 4, 2022 | Elana Gotkine / Tanat Yongpisarn et al

[ConservativeMind]

About 10 percent of patients with psoriasis have a high risk for advanced liver fibrosis, according to a systematic review and meta-analysis published online.

Tanat Yongpisarn and colleagues examined the prevalence of psoriasis patients who have a high or low risk for advanced liver fibrosis and examined risk factors for liver fibrosis using data from observational studies identified from a systematic literature review.

The researchers found that the pooled prevalence was 9.66 percent for patients with psoriasis at high risk for advanced liver fibrosis, while the pooled prevalence was 77.79 percent for patients at low risk for advanced liver fibrosis. The prevalence of advanced liver fibrosis was lower in studies that recruited methotrexate-naive patients versus methotrexate-user cohorts (4.44 versus 12.25 percent). For those of ages older than 50 years, with body mass index greater than 30 kg/m², diabetes mellitus, hypertension, dyslipidemia, and metabolic syndrome, the pooled odds ratios were 2.20, 3.67, 6.23, 2.82, 3.08, and 5.98, respectively.

"In this systematic review and meta-analysis, we discover that 9.66 percent of people with psoriasis are at high risk of having advanced liver fibrosis, necessitating further investigation and management. While 77.79 percent of the population is considered low risk, the remaining 22.21 percent requires further testing," the authors write. "We hope to inform practitioners and future researchers about the high prevalence of advanced liver fibrosis in psoriasis patients, as well as the critical need for liver fibrosis screening."

[ConservativeMind]

The connection is not clear, but there appears to be a threat of potentially worse liver conditions than one might be aware of in a reasonable proportion of psoriasis sufferers.

[ConservativeMind]

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[gr8eman]

Skin problems like I have are caused by natural liver (mal)Functions which cause blood issues. Maybe check how many of the same people have gout...which is another malady that doctors have no clue about!

[moovova]

I had a patch of psoriasis about the size of a dime on my forearm. Took forever and a couple of trips to the dermatologist to get rid of it. Doc used rub on creams. Last one did the trick. But what a nuisance...stuff is tenacious. Can’t imaging it attacking the liver.

[telescope115]

I have eczema pretty much all over, even though I am on immunosuppressants after my liver transplant, my immune system just won’t settle down. Doc has prescribed ointments, this stuff is stubborn.
I could end up needing another transplant someday, hopefully not. I would rather not have to deal with that again…

[joe fonebone]

Have you tried light therapy?
UVB narrower band works miracles

[telescope115]

I’ll have to investigate that. Thanks!