Wow. I only use 2-3 scenery mods, and the armory mod near that first town.
Right now I can guarantee myself a completely stable build on landscape, but once I start modifying my Senior combat build and the animation list it gets a little unstable. Mostly memory leaks and I usually just restart the PC as opposed to hunting down why I cannot access a particular memory block. It corrects itself on reboot and I can play with stability for hours.
My current build is just 640 high quality mods. Everything is touched, totally different experience from “vanilla”.