Yes.
It is TLDR response. I am sorry for that, the subject is just complicated.
This first link is to a reasonable explanation of ADE by an author who actually is in favor of the mRNA treatment and assesses the risk as minimal. I do not find his assessments at all reassuring.
https://davidson.weizmann.ac.il/en/online/reasonabledoubt/ade-and-corona-vaccines
The money quote:
"During experiments performed in the processes of creating vaccines against MERS and SARS, based on inactivated or engineered viruses, ADE was observed in some cases after experimental animal subjects encountered a live virus. Therefore, in pre-clinical trials the concern was raised..."
He is alluding to earlier projects in which all of the test animals died.
To be sure, this was not COVID-19. The experiments were using other coronaviruses from a decade earlier and more. Also note; these were tests of conventional vaccines using inactivated virus rather than the mRNA treatment. The Moderna researchers specifically attempted to avoid ADE reactions by generating the spike protein as the target for immune system response.
Now we are seeing that the spike protein by itself is toxic and provokes pathological blood clotting activity as it circulates through the body.
I just hate it when things like that happen. They happen often when dealing with complex systems. It is wise to be cautious.
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This link is to a research program for SARS in which the test animals were euthanized as you mentioned.
https://pubmed.ncbi.nlm.nih.gov/22536382/
"Immunization with SARS coronavirus vaccines leads to pulmonary immunopathology on challenge with the SARS virus"
Read it carefully, especially the finding that"All mice exhibited histopathologic changes in lungs two days after challenge including all animals vaccinated..."
These animals were dying from ADE. All of them. They were of course sacrificed before the reaction would have killed them. The researchers performed autopsies. That is just how this sort of research works.
See also the conclusion: "Caution in proceeding to application of a SARS-CoV vaccine in humans is indicated."
This is a more detailed account of this unfortunate experiment. It was not the first of its' kind.
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0035421
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Some additional light reading for you if you are so inclined:
References:
(1). Tseng, C-T., Sbrana, E., Iwata-Yoshikawa, N., Newman, P.C., Garron, T., et al. (2012) Immunization with SARS coronavirus vaccines leads to pulmonary immunopathology on challenge with the SARS virus. PLoS ONE 7(4): e35421. doi:10.1371/journal.pone.0035421.
(2). Bolles, M.,Deming, D.,Long,K., Agnihothram,S., Whitmore,A. Ferris,M.,Gralinski,L., Totura,A., Heise,M., Ralph S. Baric, R.S., (2011, December). A double-inactivated Severe Acute Respiratory Syndrome coronavirus vaccine provides incomplete protection in mice and induces increased eosinophilic proinflammatory pulmonary response upon challenge. J Virol. 85(23):12201-12215. doi:10.1128/JVI.06048-11
(3). Weingartl, H., Czub, M., Czub, S., Neufeld, J., Marszal, P., Gren, J., et al. (2004). Immunization with modified vaccinia virus Ankara-based recombinant vaccine against severe acute respiratory syndrome is associated with enhanced hepatitis in ferrets. J Virol. 78:12672–6.
(4). Marshall, E., Enserink, M. (2004,February 13). Caution urged on SARS vaccines. Science 303(5660):944-946. DOI: 10.1126/science.303.5660.944
https://science.sciencemag.org/content/303/5660/944
(5). Moderna’s Clinical Trial Results COVID Vaccine Could Not Be Much Worse
https://www.globalresearch.ca/moderna-covid-vaccine-trials/5713705
(6). Moderna’s Covid-19 vaccine trial shows positive early results
https://www.pna.gov.ph/articles/1103294
(7). Moderna’s coronavirus vaccine just showed signs of success in a preliminary study, raising early hopes in the fight against the pandemic
https://www.businessinsider.com/moderna-coronavirus-vaccine-releases-first-human-trial-results-2020-5
(8). Early results from Moderna coronavirus vaccine trial show participants developed antibodies against the virus
https://cnnphilippines.com/world/2020/5/18/Moderna-covid-vaccine-trial-early-results.html?fbclid=IwAR1H6tl9aQ7G8Aa2ffy0j8s4K9OUZLGW2hchjF5CTh9qRftJb8QnIhyum0w
(9). Moderna’s Guinea Pig … “Sickest in His Life” after Being Injected with Experimental Vaccine
https://childrenshealthdefense.org/news/modernas-guinea-pig-sickest-in-his-life-after-being-injected-with- experimental-vaccine/?utm_source=salsa&eType=EmailBlastContent&eId=626cd580-34cd-46ad-81dd- 2ee67e2404c8
(10). mRNA vaccines – a new era in vaccinology
https://pubmed.ncbi.nlm.nih.gov/29326426/
(11). Components of mRNA Technology “Could Lead to Significant Adverse Events in One or More of Our Clinical Trials”
https://childrenshealthdefense.org/news/components-of-mrna-technology-could-lead-to-significant-adverse-events- in-one-or-more-of-our-clinical-trials-says-moderna/
(12). Lipid Nanoparticles Entails a Biphasic Humoral Response
https://www.immunohorizons.org/content/3/7/282
(13). Use of Genetically Modified Viruses and Genetically Engineered Virus-vector Vaccines: Environmental Effects.
https://www.tandfonline.com/doi/abs/10.1080/15287390600751405? scroll=top&needAccess=true&journalCode=uteh20)
(14). Infectious Laryngotracheitis Virus_Vaccine Virulent Recombination_poultry.
https://pubmed.ncbi.nlm.nih.gov/25785629/
(15). Unique safety issues associated with virus-vectored vaccines
https://europepmc.org/article/pmc/pmc5204448
(16). Unproven strategies lead the race for a COVID-19 vaccine
https://www.theverge.com/2020/5/22/21266897/coronavirus-vaccine-development-strategies-pros-cons
(17). Safety, tolerability, and immunogenicity of a recombinant adenovirus type-5 vectored COVID-19 vaccine.
https://www.thelancet.com/lancet/article/s0140673620312083
(18). Quijano, R.F., Altermidya (2018, January 10). The Dengvaxia Fiasco: Symptom of a Deeper Malady.
https://www.altermidya.net/dengvaxia-fiasco-symptom-deeper-malady/
(19). Erfe, E., Facebook post (2020, February 18). Dengvaxia victim No. 153.
httphttps://www.govinfo.gov/content/pkg/CREC-2003-05-21/html/CREC-2003-05-21-pt1-s://www.facebook.com/attyerwinerfe/
Multiple links.
Well done.
thanks- something must have changed in the vaccinations, because folks are still getting the virus after getting the vaccination, but for the most part, they aren’t dying from the body’s reaction to the virus-
A coup-le of folks i guess did die- but most folks who get the breakthrough cases are surviving without complications... at least short term-
[[I just hate it when things like that happen. They happen often when dealing with complex systems. It is wise to be cautious. ]]
Exactly- the body is super complex- and what may be fine for most, will affect others badly- all these drugs on the market come with long lists of symptoms that they could cause, but most will never experience them, while some will- the question is how many?
I don’t think they went from “Vaccine kills all test animals” to “Let’s give it to everyone and see what happens”- i think somewhere along the line, it was tested for safety- it had to be- (I hope so anyways!)- The lawsuits over something that is totally untested, or known to be dangerous, would bankrupt the companies-
Yup- we should proceed with caution- So far there is clotting going on, and heart issues, some have suffered other things too like temporary blindness-
my personal feeling about it all is that only the elderly with preexisting conditions should have been offered it IF they chose to take it- Everyone else has a 99+% chance of surviving the virus fine- kids definitely should not be getting it- they have almost a 100% chance of surviving it, and they don’t pass it along to others supposedly- or rarely do or something like that