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While there is considerable hope with the HCQ regimen, and considerable early success reported, there is still reason to be cautious about broad proactive prescription, and studies should still be done as able to determine the actual best dosage and best timing and criteria.

Combinations of certain diseases with certain drugs - even drugs with a long history of safety with other diseases - can still lead to long-term side effects. Not that that matters so much in regards those cases that appear to be going terminal.

Here’s an example:
https://www.mayoclinic.org/diseases-conditions/reyes-syndrome/symptoms-causes/syc-20377255

“Reye’s (Reye) syndrome is a rare but serious condition that causes swelling in the liver and brain. Reye’s syndrome most often affects children and teenagers recovering from a viral infection, most commonly the flu or chickenpox.

“Signs and symptoms such as confusion, seizures and loss of consciousness require emergency treatment. Early diagnosis and treatment of Reye’s syndrome can save a child’s life.

“Aspirin has been linked with Reye’s syndrome, so use caution when giving aspirin to children or teenagers for fever or pain. Though aspirin is approved for use in children older than age 3, children and teenagers recovering from chickenpox or flu-like symptoms should never take aspirin.”

…

“There’s one caveat to the aspirin rule, however. Children and teenagers who have certain chronic diseases, such as Kawasaki disease, may need long-term treatment with drugs that contain aspirin.

“If your child needs aspirin therapy, make sure his or her vaccines are current — including two doses of the varicella (chickenpox) vaccine and a yearly flu vaccine. Avoiding these two viral illnesses can help prevent Reye’s syndrome.”

Reyes syndrome can cause permanent retardation as an after-effect.