In the 30-pack, I think they were called 304 suppositories. I knew there was a number in there somewhere. Just couldn't remember what it was. Purely innocent.
Posted on 07/03/2019 6:48:47 PM PDT by BenLurkin
Cannabis suppositories have grown in popularity, but how and to what extent they actually work remains a mystery. With contradictory claims from proponents and skeptics regarding the rectal bioavailability of THC, intoxication (or lack thereof), and alleviation of symptoms of difficult-to-treat diseases, it’s time to get a grip on what we really know about this method of administering cannabis.
Clinical research on cannabis suppositories is still limited. Much of the available data pertains to experiments conducted on animals, not on people who actually use suppositories. Despite the distinct lack of clinical studies, anecdotal accounts from patients are often very positive. The overwhelming majority of patient reports have one thing in common: a lack of intoxication that’s typically caused by smoking or ingesting THC-rich cannabis.
The absence of a “head high” would seem to indicate that a suppository does not distribute a systemic dose of cannabis – which corroborates initial research findings about limited bioavailability. This suggests that a suppository acts more like a topical with a local effect, rather than a transdermal patch which disseminates medicine systemically through the bloodstream.
Why suppositories?
Rectal and vaginal suppositories have both been used to deliver medicine to patients for decades. The pelvic region houses a matrix of nerves that travel to the legs and up the spine, and the colon contains cannabinoid receptors (CB1 and CB2), which mediate many of THC’s effects.
Generally, cannabis suppositories are made by combining cannabis-infused oils in a carrier oil that hardens at low temperatures. Rectal administration of cannabis oil may activate the cannabinoid receptors located there, which could be beneficial for local conditions like hemorrhoids or acute inflammation [6]. The rectum also contains a number of key veins that deliver blood to the entire body, but it doesn’t appear that suppositories facilitate cannabinoid absorption into the bloodstream.
(Excerpt) Read more at projectcbd.org ...
They taste terrible.
Mayor pete sez: “hell, yeah”
American culture continues its descent
You go first.
Coconut oil marijuana suppositories to relax your special parts
for the magic moment
Of course they work, but most dopers use tennis balls or hamsters.
I don’t know, but 308 suppositories work great on perverts who are trying to destroy your country.
Well, if ya have to do it, this way has gotta be a better delivery system than crammin’ a Bong up there.
It’s ‘gas, grass, and a$$’ not ‘gas, grass in a$$.’
They’re hard to swallow and for all the good they do, you might as well shove them up your butt.
Not as well as suppository breath mints.
Rectum?
Wrecked ‘em? Damn near killed ‘em!
Ask Buttiegig
In the 30-pack, I think they were called 304 suppositories. I knew there was a number in there somewhere. Just couldn't remember what it was. Purely innocent.
Try a bong water enema first.
Depends if the suppository is sativa or indica.
I completely reject this entire concept. You can take your damn cannabis and shove it up your ass!
Impossible to keep lit.
Bravo. Well said.
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