It is on both sides of my Family. Please let me test!
Ex wife’s grandfather had it, childhood best friend’s mom had it, bad stuff. The wife of a good friend of mine is in the same boat as you. Genes on both sides. Every time she forgets something it scares her. Allergic to darn near everything, she does keto diet in addition to gluten free and dairy free. Anything they say helps. It is a struggle. I pray the Lord lead these researchers to a cure.
[0014] We have discovered that triclabendazole (TCBZ) and fenbendazole (FBDZ) are effective in extending the lifespan of yeast and mammalian cells (a model for apoptosis), in increasing protection for cells from oxidative stress, and in protecting against diseases based on toxic protein aggregates or "proteinopathies," for example, Parkinson's disease and the related protein alpha-synuclein. Both triclabendazole and fenbendazole can be used to extend the lifespan of eukaryotic cells, protect cells from oxidative stress, and treat various neurodegenerative diseases that are known to involve toxic protein aggregates, for example, amyotrophic lateral sclerosis (ALS), Alzheimer's disease (AD), Parkinson's disease (PD), prion diseases, polyglutamine expansion diseases (e.g., Huntington's disease (HD)) and tauopathies (e.g., AD, frontotemporal dementia associated with tau-immunoreactive inclusions (FTD-tau), progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD)). We have shown that that TCBZ and FBDZ increase the yeast chronological lifespan and protect yeast and mammalian cells from various stresses. In addition, both TCBZ and FBDZ decreased the level of cAMP in yeast and human cells. We believe the mechanism is by inhibiting the enzyme adenylate cyclase. In addition, we discovered that the human Parkinson's disease-related protein alpha-synuclein increased cAMP in yeast cells, and this increase could be inhibited by TCBZ. Thus both TCBZ and FBDZ can be used to treat Parkinson's disease. In addition, TCBZ and FBDZ can be used to treat symptoms of other diseases caused by protein aggregation (e.g., AD, HD, ALS, etc.). We believe that close derivatives or metabolites of either TCBZ or FBDZ would have similar effects. Known metabolites of TCBZ include a sulfoxide (TCBZ-SO) and a sulfone (TCBZ-S02). Similar metabolites of FBDZ include a sulfoxide (FBDZ-SO) and a sulfone (FBDZ-S02). In addition, since both TCBZ and FDBZ are low molecular mass compounds and hydrophobic, it is believed that both would cross the blood-brain barrier.