Schematic diagram of a conceptual SWR model, including pyramidal cells (PC), basket cells (BC), bistratified cells (BS), axo-axonic cells (AAC)
and oriens-lacunosum moleculare cells (OLM). Thin lines represent dendritic arborizations and thick lines are axonal ones. Dashed lines represent
inputs arriving from CA3 through the Schaffer collaterals (blue) or the medial septum (MS, purple). The representative spiking activity of BS, BC
and PC cells during SWRs is shown above the corresponding cells. In the model, the BS cells will respond to the CA3 input by fast spiking which
abolishes dendritic electrogenesis and somatic bursting in the PCs. BC cells also spike fast and due to their recurrent inhibition, synchronize their
firing in ripple frequencies, imposing this rhythm on the BS population as well (red and green ripple-frequency spikes). Hence, PCs receive
synchronous ripple-frequency inhibitory inputs in their dendritic and perisomatic areas (green and red ripples) along with excitatory input in their
apical dendrites (blue, sharp-wave), yielding ripple-frequency intracellular oscillations and ripple phase-locked sparse firing (black trace). A schematic SWR LFP that would result from this activity is shown on left. AA cells also received the CA3 excitation, but respond only during the
initial stages of SWRs as MS inhibition later dominates (cyan trace). Finally, the OLM cell remains silent throughout the main SWR event, due to
the MS inhibition and the lack of any CA3 excitation, only being able to spike at later stages of SWRs when the excitation from CA1 cells has
built up (brown trace). Top timescale corresponds to LFPs; bottom one to all spiking and synaptic traces. All traces are conceptual and start at the
same timepoint.
So, lets see: bravery is feeling safe in a risky environment. Really?
Not quite. Bravery is submerging your own fear, your own dread and doing the right thing anyway.
Theres all kinds of bravery too. Husbands who stay faithful even when a pass is hard to resist, people who leave notes when they ding someones car while parking, people who tell the truth, even when they know it will have bad consequences.
Some wonderful egghead scientist figures that hes found the key to bravery - really? He hasnt been out in the world much, has he.
You can get exactly the version of bravery they are describing by getting drunk.