I personally believe the introduction of the spreadsheet in the mid 80’s contributed greatly to the Wall-Street LBO and takeover boom of the 2nd half of that decade.
It was a brand new phenomenon, analysts being able to run many, various, complex financial and operating scenarios extremely quickly.
Many businesses were destroyed and many people lost their jobs due to a new type of cube dweller: the MBA spreadsheet monkey. While spreadsheets are great for inputting numbers, it's very difficult to input non-numbers like quality, skill, and wisdom.