We put a new "organic" head on an antique banjo in ~ 1970. Last time I saw the instrument (<5 year ago) the head had split again...
I suspect that the organic head will have a more mellow or muffled tone than a synthetic head.
I had a single synthetic head on my banjo since I bought it in 1968. I only replaced it recently because the old one was dirty and worn looking. I was restoring the banjo and the new Remo head looks awesome. Sounds good too.