As cloudmountain said, the Swinging 60's did a lot of damage.
I don’t think that I understand what you’re trying to say. Isn’t spiking someone’s drink a bad thing?
It’s hard to know where change leads.
The twenties broke new ground in what was acceptable culturally, women’s voting, urban overtook rural, cigarette smoking, fashion, etc. The freed up social norms regressed somewhat during the Depression, with weed becoming illegal and the attempt at Prohibition failing. All this gave us the buttoned-down fifties.
The sixties broke ground again with the sexual revolution, ascendance of leftism in academe and women’s lib.
I’d have to say the twenties left us better off while the sixties pushed us irretrievably left, to great disadvantage.