Yes. Unless you've got a mission critical application that requires it, you can uninstall it and not look back. According to its Wikipedia page:
Microsoft announced the end of life of Silverlight 5 [the most current version] in 2012. In 2013, Microsoft announced that they had ceased development of Silverlight except for patches and bugfixes. Silverlight is no longer supported in Chrome on OS X, while support for Silverlight in Chrome on all other operating systems was disabled by default in April 2015 and was removed completely in September 2015. Microsoft has set the support end date for Silverlight 5 to be October 2021. In 2015, Microsoft announced that since support for ActiveX was discontinued with Microsoft Edge, Silverlight will not be supported in that browser.I'd say you're safe. Not only has there been no reason for developers to write for it for many years, the fact that Windows 10 Edge does not support it is the death knell.
Thanks, it will be uninstalled ASAP.
Dang it!