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Sodium Reduction in Populations - Insights From the Institute of Medicine Committee
JAMA ^ | June 6, 2013 | Brian L. Strom, MD, MPH; Cheryl A. M. Anderson, PhD, MPH, MS; Joachim H. Ix, MD, MAS

Posted on 06/07/2013 10:33:05 PM PDT by neverdem

The recent Institute of Medicine (IOM) report regarding dietary sodium1 has generated considerable interest and debate, as well as misinterpretation by advocates on both sides. Further discussion is necessary to inform the public and the health care community and to inform public health strategies for sodium reduction.

CURRENT PUBLIC HEALTH RECOMMENDATIONS REGARDING DIETARY SODIUM

Dietary sodium intake averages approximately 3400 mg/d in US adults, far in excess of the Dietary Guidelines for Americans (DGA) recommendation of less than 2300 mg/d for those older than 2 years and less than 1500 mg/d for certain high-risk subgroups, including African Americans, individuals with hypertension, diabetes, or chronic kidney disease (CKD), or those older than 50 years.2 In contrast, the 2005 IOM Panel on Dietary Reference Intakes (DRI) for Water, Potassium, Sodium, Chloride, and Sulfate3 found insufficient evidence to derive a “recommended dietary allowance” for sodium. Instead, an “adequate intake” of 1500 mg/d of dietary sodium was determined, reflecting the minimum needed to achieve a diet adequate in essential nutrients and to cover sweat losses. Additionally, the 2005 IOM panel established a “tolerable upper intake level,” using projections from available data on the effects on blood pressure, that consumption up to 2300 mg/d was unlikely to cause harm.

Based on the strength of the blood pressure data, various US (eg, American Heart Association [AHA]) and international (eg, World Health Organization [WHO]) organizations published recommendations for sodium consumption.4- 5 Although these recommendations were somewhat different from the DGA, there was general agreement that sodium consumption is excessive worldwide and should be reduced. Despite these recommendations, more than 90% of US adults consume more than 2300 mg of sodium per day, and among the high-risk subgroups more than 98% consume more than 1500 mg of sodium per day.6

A substantial body of evidence supports efforts to reduce sodium intake. This evidence links excessive dietary sodium to high blood pressure, stroke, and cardiovascular disease (CVD).1 However, effects of sodium on blood pressure cannot always be disentangled from effects of total dietary modification, and effects of other electrolytes on blood pressure remain unresolved.7 Concerns have been raised that a very low sodium intake may adversely affect lipids, insulin resistance, renin, and aldosterone levels and potentially may increase risk of CVD and stroke. Some studies link sodium intakes of less than 2300 mg/d to increased risk of CVD, at least in subpopulations. Thus, debate emerged about the sodium intake target that best improves health outcomes.

In response, the US Centers for Disease Control and Prevention commissioned the IOM to convene an expert committee to examine the designs, methods, and conclusions of literature published since the 2005 DRI report.3 Specifically, the committee was asked to review and assess potential benefits and adverse outcomes of reducing sodium intake in the population, particularly in the range of 1500 to 2300 mg/d, with emphasis on the high-risk subgroups. The committee was asked to focus on studies of direct health outcomes (vs surrogate end points such as blood pressure), to comment on implications for population-based strategies to reduce sodium intake, and to identify methodologic gaps and ways to address them. The committee's full report is published elsewhere.1

SODIUM AND DIRECT HEALTH OUTCOMES

The committee searched literature published through 2012 for relevant publications. Information also was gathered from an open public workshop. Although not its primary emphasis, the committee summarized studies published since 2003 evaluating intermediate markers, particularly blood pressure. Focusing on CVD outcomes, the committee's assessment of evidence was guided by factors such as study design, quantitative measures of dietary sodium intake, confounder adjustment, and number and consistency of available studies.

FINDINGS AND CONCLUSIONS

General US Population. Studies linking dietary sodium intake with direct health outcomes were highly variable in methodological quality; limitations included overreporting or underreporting of sodium intake. However, when considered collectively, the evidence on direct health outcomes indicates a positive relationship between higher levels of sodium intake and risk of CVD, consistent with the known effects of sodium intake on blood pressure. Furthermore, in some studies, the association between sodium and CVD outcomes persisted after adjusting for blood pressure, suggesting that associations between sodium and CVD may be mediated through other factors (eg, effects of other electrolytes) or through pathways other than blood pressure.

Studies evaluating sodium intake in the range of 1500 to 2300 mg/d demonstrate evidence of blood pressure lowering, but no studies have examined sodium intake in that range in the general population and direct CVD outcomes. The committee found that studies on direct health outcomes were of inconsistent quality and insufficient quantity to conclude whether sodium intake of less than 2300 mg/d was associated with either a greater or lesser risk of CVD.

Population Subgroups. The committee reviewed multiple randomized trials conducted by a single team that indicated low sodium intake (up to 1840 mg/d) may lead to greater risk of adverse events in patients with heart failure (HF) with reduced ejection fraction who received aggressive therapeutic regimens. Because these therapeutic regimens were different from standard US practice, trials using regimens that more closely resemble standard US clinical practice are needed. Of note, due to allegations of duplicate publication in 2 of these trials, a meta-analysis including them was recently retracted, after the IOM report's completion.8 Another recently published small randomized trial involving patients with acute decompensated HF showed no benefit on weight or clinical stability from a combination of sodium and fluid restriction.9

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The committee reviewed 2 related studies in individuals with prehypertension that suggested benefit from lowering sodium intake to 2300 mg/d and perhaps lower, although these studies were based on small numbers of persons with sodium intake in the less than 2300 mg/d range. In contrast, for patients with diabetes, CKD, or preexisting CVD, the committee found no evidence of benefit and some evidence suggesting risk of adverse health outcomes at sodium intake of 1500 to 2300 mg/d. In studies that explored statistical interactions, race, age, hypertension, and diabetes did not modify associations of sodium with health outcomes. The committee concluded that, with the exception of heart failure, evidence of both benefit and harm is not strong enough to indicate that these subgroups should be treated differently from the general US population. Thus, the committee also concluded that evidence on direct health outcomes does not support recommendations to lower sodium intake within these subgroups to or even less than 1500 mg/d.

IMPLICATIONS FOR POPULATION-BASED STRATEGIES TO GRADUALLY REDUCE SODIUM INTAKE

Although not asked to specify targets for dietary sodium, the committee noted factors that precluded establishing these targets. These include lack of consistency in methods for defining sodium intakes at both high and low ends of typical intakes and extreme variability in intake levels across studies. The committee could only consider sodium intake levels within the context of each individual study because there were impediments to calibrating sodium assessment measures across studies.

After release of the IOM report, several news outlets highlighted disagreement among health agencies about targets for dietary sodium intake and reported that experts disagreed about the importance of blood pressure. Focusing the debate on specific targets misses the larger conclusion with which all are in agreement and may hinder implementation of important public health policy. Rather than focusing on disagreements about specific targets that currently affect less than 10% of the US population (ie, sodium intake of <2300 mg/d vs <1500 mg/d), the IOM, AHA, WHO, and DGA are congruent in suggesting that excess sodium intake should be reduced, and this is likely to have significant public health effects. Accomplishing such a reduction will require efforts to decrease sodium in the food environment10 and provide individual consumers more choice in their dietary consumption of sodium.

AUTHOR INFORMATION

Corresponding Author: Brian L. Strom, MD, MPH, Perelman School of Medicine at the University of Pennsylvania, 237 John Morgan Bldg, 3620 Hamilton Walk, Philadelphia, PA 19104-6055 (bstrom@mail.med.upenn.edu).

Published Online: June 6, 2013 doi:10.1001/jama.2013.7687

Conflict of Interest Disclosures: All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest and none were reported.

Funding/Support: The work of this committee was funded by a contract from the Centers for Disease Control and Prevention to the IOM. No support was provided for the writing of this article.

Disclaimer: The opinions expressed are those of the authors and should not be construed as policies of the IOM or any organizations with which the authors are affiliated.

Additional Contributions: We thank the senior staff of the IOM Committee on the Consequences of Sodium Reduction in Populations, Ann L. Yaktine and Maria Oria, and the other committee members: Jamy Ard, Kirsten Bibbins-Domingo, Nancy Cook, Mary Kay Fox, Niels Graudal, Jiang He, Stephen Kimmel, Alice Lichtenstein, and Myron Weinberger. We are also grateful to the IOM peer review process, overseen by the Report Review Committee, which resulted in a much improved report.

REFERENCES

Institute of Medicine. Sodium Intake in Populations: Assessment of Evidence. Washington, DC: National Academies Press. http://www.iom.edu/Reports/2013/Sodium-Intake-in-Populations-Assessment-of-Evidence.aspx. May 2013. Accessed June 4, 2013
US Department of Agriculture and US Department of Health and Human Services. Dietary Guidelines for Americans, 2010. 7th ed. Washington, DC: US Government Printing Office; 2010
Institute of Medicine. Dietary Reference Intakes for Water, Potassium, Sodium, Chloride, and Sulfate. Washington, DC: National Academies Press; 2005
Appel LJ, Frohlich ED, Hall JE, et al. The importance of population-wide sodium reduction as a means to prevent cardiovascular disease and stroke: a call to action from the American Heart Association. Circulation. 2011;123(10):1138-1143
PubMed | Link to Article
World Health Organization. Guideline: Sodium Intake for Adults and Children. Geneva, Switzerland: World Health Organization; 2012
Cogswell ME, Zhang Z, Carriquiry AL, et al. Sodium and potassium intakes among US adults: NHANES 2003-2008. Am J Clin Nutr. 2012;96(3):647-657
PubMed | Link to Article
US Department of Agriculture and US Department of Health and Human Services. Report of the Dietary Guidelines Advisory Committee on the Dietary Guidelines for Americans, 2010, to the Secretary of Agriculture and the Secretary of Health and Human Services. Washington, DC: USDA/ARS; 2010
Low sodium versus normal sodium diets in systolic heart failure: systematic review and meta-analysis [retraction]. heart.bmj.com/content/early/2013/03/12/heartjnl-2012-302337.extract. Accessed May 23, 2013
Aliti GB, Rabelo ER, Clausell N, Rohde LE, Biolo A, Beck-da-Silva L. Aggressive fluid and sodium restriction in acute decompensated heart failure: a randomized clinical trial. JAMA Intern Med
PubMed | Link to Article
Institute of Medicine. Strategies to Reduce Sodium Intake in the United States. Washington, DC: National Academies Press; 2010


TOPICS: Health/Medicine
KEYWORDS: health; publichealth; sodium
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1 posted on 06/07/2013 10:33:06 PM PDT by neverdem
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To: neverdem

How much time do you spend reading every day?


2 posted on 06/07/2013 10:47:58 PM PDT by Carry_Okie (An economy is not a zero-sum game, but politics usually is.)
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To: neverdem

The effects of sodium intake depend on one’s diet. On a high carb diet (like the so-called healthy food pyramid) one retains excess sodium, hence the warnings to restrict sodium intake. On a lower carb diet this is not an issue.


3 posted on 06/07/2013 10:48:16 PM PDT by Diapason
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To: Diapason
The effects of sodium intake depend on one’s diet. On a high carb diet (like the so-called healthy food pyramid) one retains excess sodium, hence the warnings to restrict sodium intake. On a lower carb diet this is not an issue.

This is another Atkins myth. The harmful effects of excess sodium intake do not vary by diet. Carbohydrate consumption is not a factor.

4 posted on 06/07/2013 11:02:38 PM PDT by Praxeologue
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To: Kennard

Unless you have certain genetic factors “harmful effects of excess sodium intake” is what is a myth.


5 posted on 06/07/2013 11:05:54 PM PDT by Harmless Teddy Bear (Join AAAA : Americans Against Acronym Abuse)
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To: neverdem

Just based on my individual experience, sodium is by far the worst chemical which affects my body negatively. Sugar I can burn up by lots of activity, but excess sodium is hard to get rid of, especially in cool climate such as here in Seattle area. NaCl most certainly raises my BP which then has cascading bad effects on other issues.


6 posted on 06/07/2013 11:14:29 PM PDT by entropy12 (Even tho Obama is now a lame duck, with 2014 House majority, he will be a dangerously socialist!)
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To: Carry_Okie

Often, a lot, but there can be wide variations.


7 posted on 06/07/2013 11:56:56 PM PDT by neverdem (Register pressure cookers! /s)
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To: Kennard

“This is another Atkins myth. The harmful effects of excess sodium intake do not vary by diet. Carbohydrate consumption is not a factor.”

I don’t know what Atkins said about salt. All I know is about more recent research which my own doctor seems to be familiar with, and which has led me into trying to up my sodium intake in spite of the fact that I just don’t like the taste of salt – I prefer the taste of food without it. For the record, I ended up with very high blood pressure in spite of very limited sodium intake. Since going lower carb – never particularly high to start with – my blood pressure meds have been reduced along with hypothyroid meds (born defective ;-) and ditched 8kg.


8 posted on 06/08/2013 12:01:22 AM PDT by Diapason
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To: El Gato; Ernest_at_the_Beach; Robert A. Cook, PE; lepton; LadyDoc; jb6; tiamat; PGalt; Dianna; ...
Examining the Health Effects of Fructose

Don't pull diabetes drug Avandia off the market, FDA panel urges

Obesity surgery can stop diabetes better than drugs -- with risks

Atomic Bombs Help Solve Brain Mystery

FReepmail me if you want on or off my health and science ping list.

9 posted on 06/08/2013 12:27:18 AM PDT by neverdem (Register pressure cookers! /s)
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To: Diapason
For the record, I ended up with very high blood pressure in spite of very limited sodium intake.

ditto! Didn't know about the carb thing, thanks!

10 posted on 06/08/2013 12:45:52 AM PDT by presently no screen name
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To: entropy12

And I’m just the opposite. Sodium seems to get flushed out of my system rapidly, but sugar sticks around and causes weight gain in very little time.


11 posted on 06/08/2013 2:39:20 AM PDT by whatshotandwhatsnot (Islam Wants You Dead!)
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To: Harmless Teddy Bear; All
Unless you have certain genetic factors “harmful effects of excess sodium intake” is what is a myth.

Bravo! Not many people or doctors know this.

A couple articles.

http://www.scientificamerican.com/article.cfm?id=what-science-on-hypertension-really-shows

Interesting exerpts:

"Indeed, research doesn't always support the notion that salt causes high blood pressure: A large, multicenter study known as INTERSALT compared urinary sodium levels—an accurate indicator of prior sodium consumption—with hypertension in more than 10,000 people in 1988 and found no statistically significant association between them. In fact, the population that ate the most sodium had a lower median blood pressure than the population that ate the least."

"They found, surprisingly, that the more sodium their subjects ate, the less likely they were to die. In particular, the death rate among those eating the least sodium was 4.1 percent, but it was only 0.8 percent among avid salt consumers."

http://www.ncbi.nlm.nih.gov/pubmed/22639013

The conclusion:

"Taken together, these data provide strong support for a "J-shaped" relation of sodium to cardiovascular outcomes. Sodium intakes above and below the range of 2.5 to 6.0 grams/day are associated with increased cardiovascular risk. This robust body of evidence does not support universal reduction of sodium intake."

12 posted on 06/08/2013 3:40:19 AM PDT by Right Wing Assault (Dick Obama is more inexperienced now than he was before he was elected.)
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To: neverdem

About 25 years ago, I was administered a 24 hour urine renin test at the Cornell Hospital hypertension clinic. It consisted of my having to collect my urine for 24 hours and take it to Cornell for analysis. Based on that test (I actually took it twice), I was told that I was not “salt sensitive,” and that I did not need to restrict my salt intake.

The physicians there also told me that the majority of people do not need to restrict salt intake, but because there are a small number of people who do, and the 24 test is unwieldy and expensive, it’s easier, from a public health standpoint to simply advise people to reduce their salt intake.


13 posted on 06/08/2013 4:43:25 AM PDT by Salvey
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To: Diapason

My doctor has never mentioned restricitng salt intake in spite of the fact as I have aged my blood pressure has risen.

My semianual blood work measures the sodium level. It is always comfortably below the upper limit. Rather than try to measure consumption, it is easier to measure the effect, blood sodium level. When it passed the limit over a 6 monyh interval he medicated

Unlike you, I crave salt and unlike my wife who is like you, add salt to most food


14 posted on 06/08/2013 4:45:39 AM PDT by bert ((K.E. N.P. N.C. +12 .....Lerner must be tried and executed..... crime against the Republic)
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To: bert

When I was in football we took salt tablets daily, when in the Army we did the same thing when on patrol. The A Shau would suck the water out of a man in short order, salt tabs helped to retain fluids. You couldn’t carry enough water if you didn’t.


15 posted on 06/08/2013 5:03:58 AM PDT by Dusty Road
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To: neverdem

I wonder what the effects would be if the “total salt” levels in food were allowed to remain as they are, but for that total level to be a combination of sodium and potassium chloride with the ratio set to what is the optimum for good health.


16 posted on 06/08/2013 5:29:20 AM PDT by Wonder Warthog
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To: neverdem
Focusing the debate on specific targets misses the larger conclusion with which all are in agreement and may hinder implementation of important public health policy.

And there's the money quote.

17 posted on 06/08/2013 5:39:39 AM PDT by VeniVidiVici (Obama's Enemies List - Yes, you are a crook.)
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To: Diapason
The effects of sodium intake depend on one’s diet. On a high carb diet (like the so-called healthy food pyramid) one retains excess sodium, hence the warnings to restrict sodium intake. On a lower carb diet this is not an issue.

You are spot on correct. I do not eat carbs (sub 30g per day), and need to supplement my sodium daily by consuming broth made from bullion cubes.

18 posted on 06/08/2013 5:53:33 AM PDT by RobertClark (My shrink just killed himself - he blamed me in his note!)
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To: Diapason

here was a study done a few years ago that found that people tended to unconsciously self regulate salt intake as the level fluctuated in their bodies. If things taste salty to you I’d say that’s a good indication that you don’t need anymore.


19 posted on 06/08/2013 6:00:16 AM PDT by TalBlack (Evil doesn't have a day job.)
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To: Harmless Teddy Bear
Unless you have certain genetic factors “harmful effects of excess sodium intake” is what is a myth.

Excess sodium intake has a high correlation to cardiovascular disease, according to every major medical research hospital.

Those, like Atkins, who preach yo-yo low carb diets, while ignoring the dangers of sodium, are pandering to our addiction to salt and doing a disservice to us all, to sell books and services.

No one, however, including Bloomberg, should dictate what we eat, or smoke. Caveat vorator.

20 posted on 06/08/2013 7:32:01 AM PDT by Praxeologue
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