My brother is going through the same thing.
Something to consider for your brother (and the other poster with arthritis)is that most of these symptoms (high blood pressure, depression, diabetes, arthritis, and many others) are caused by magnesium deficiency. Mag is alkaline and causes inflammation to subside. It also is necessary for calcium to dissolve and absorb. Arthritis is calcified crystals around the joints.
Take 800-900 mg of mag malate or mag glyinate per day and you’ll see huge strides in general health.
I’m sorry for you AppyPappay. You have my sympathy.